Anti-CD19 Monoclonal Antibody (FMC63)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC031	Anti-CD19 Antibody (FMC63)	Mouse IgG2a, Kappa		None	$460	In stock	Add
ASPC031-1	Anti-CD19 Antibody (FMC63), Fab fragment	Mouse Fab	His tag	None	$460	In stock	Add
ASPC031-P	Anti-CD19 Antibody (FMC63), PE	Mouse IgG2a, Kappa		PE	$1,180	2-3 weeks	Add
ASPC031-A	Anti-CD19 Antibody (FMC63), APC	Mouse IgG2a, Kappa		APC	$980	2-3 weeks	Add
ASPC031-H	Anti-CD19 Antibody (FMC63), HRP	Mouse IgG2a, Kappa		HRP	$600	2-3 weeks	Add
ASPC031-B	Anti-CD19 Antibody (FMC63), Biotin	Mouse IgG2a, Kappa		Biotin	$680	2-3 weeks	Add

Anti-CD19 Monoclonal Antibody (FMC63)
- Product Description:
  
  The antibody FMC63 targets the CD19 antigen. CD19 is a transmembrane protein expressed on the surface of B lymphocytes, including most B-cell leukemias and lymphomas, making it a crucial target for certain cancer therapies.
  
  Applications:
  
  Depletion, Flow Cytometry, Immunoprecipitation, Flow Cytometry, Immunofluorescence, Immunohistochemistry
  
  Source:
  
  Mouse
  
  Target:
  
  CD19
  
  Target Species:
  
  Human
  
  Specificity:
  
  Human CD19
  
  Immunogen:
  
  JVM3, a human prolymphocytic leukemia cell line.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  FMC63
  
  Isotype:
  
  Mouse IgG2a, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CD19 Monoclonal Antibody (FMC63) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CD19

Protein Name

B-lymphocyte antigen CD19

Molecular Family

CD Molecules

Introduction

This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections.

Alternative Names

CD19 Molecule; B-Lymphocyte Surface Antigen B4; T-Cell Surface Antigen Leu-12; Differentiation Antigen CD19; CD19 Antigen; B-Lymphocyte Antigen CD19; CVID3; B4

Gene ID

930

UniProt

P15391

Related Disease

Immunodeficiency, common variable, 3 (CVID3)

Tissue Specificity

Detected on marginal zone and germinal center B cells in lymph nodes. Detected on blood B cells (at protein level).

Cell Type

Dendritic cells, NK cells, T cells, Thymocytes, Tregs

Function

Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens.

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