Chlorpromazine hydrochloride - Amerigo Scientific

- Overview
  - Chlorpromazine hydrochloride is an amphiphilic drug, derivative of phenothiazine, that blocks post-synaptic dopaminergic receptors (D1-D4) in mesolimbic area (antipsychotic effects). It is an antagonist at histamine (H1), serotonin (5HT1 and 5-HT2) and alpha-1, alpha 2 adrenergic receptors and possess antimuscarinic properties. Chlorpromazine hydrochloride salt is used in the treatment of: agitation and aggression in bipolar disorder and schizophrenia, in behaviour problems and hyperactivity in children, and for the treatment of chronic hiccups. Also, it helps in: tetanus therapy and intermittent porphyria, the treatment of severe migraines, and helps control nausea and vomiting. Chlorpromazine performs clathrin- mediated endocytosis at non-toxic concentrations and it can be used as a potential broad-spectrum inhibitor of viruses.
    
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- Properties
  - Categories
    
    Fine Chemicals
    
    Alternative Name
    
    2-Chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine hydrochloride;2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine hydrochlorid e;Klorproman
    
    CAS Number
    
    69-09-0
    
    Molecular Formula
    
    C17H20Cl2N2S
    
    Molecular Weight
    
    355.33 g/mol
    
    MDL Number
    
    MFCD00012654
    
    Note
    
    There is a hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Thomas, A. Ban, (2007). Fifty years’ chlorpromazine: a historical perspective. Neuropsychiatric Disease and Treatment 3(4): 495–500.
    Ruben S. Vardanyan, Viktor J. Hruby, (2006). Synthesis of Essential Drugs. Antipsychotics (Neuroleptics) 83-101.
    Michal Otreba., et al. (2020). Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review. European Journal of Pharmacology 887, 173553.