Haloperidol

- Overview
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    Background
    
    Haloperidol is an antipsychotic drug that has similar actions to the antipsychotic medicine phenothiazine [1].Haloperidol has been reported to play a role as an inverse agonist of dopamine. In addition, Haloperidol has been found to be highlt potent neuroleptic by relieving nervous through the depression of nerve function. Besides, Haloperidol has shown about 50-fold potency than chiorpromazine, the other antipsychotic drug. Haloperidol has shown beneficial effects in the treatment of delusions and hallucinations. These effects are mainly achieved through blockage of dopamine receptors in the mesocortex and limbic system. Haloperidol has been revealed to prevent the effects of dopamine in the nigrostriatal pathways, which probably explains the associated side effects such as akathisia and dystonias[1].
    
    [1] Dr Ananya Mandal, MD .Haloperidol Pharmacology.
- Properties
  - Categories
    
    Antipsychotic drug
    
    Alternative Name
    
    4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
    
    CAS Number
    
    52-86-8
    
    Molecular Formula
    
    C21H23ClFNO2
    
    Molecular Weight
    
    375.86
    
    Appearance
    
    A solid
    
    Purity
    
    99.91%
    
    Solubility
    
    insoluble in H2O; ≥18.79 mg/mL in DMSO; ≥2.52 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
    
    * For Research Use Only