Clomipramine hydrochloride- Bio-X

- Overview
  - Clomipramine hydrochloride is the hydrochloride salt form of clomipramine, an amphiphilic drug, derivative of dibenzazepine. It is presumed that this tricyclic compound affects serotonin uptake in the brain increasing thus the activity of serotonin. Also, clomipramine reduces the re-uptake of norepinephrine (active metabolite desmethylclomipramine) and binds to alpha-adrenergic, histaminergic, and cholinergic receptors (side effects). Clomipramine is antidepressant, used to treat obsessive compulsive disorder, panic disorders and cataplexy. Clomipramine is shown to modulate immune activation, shows constant anti-inflammatory properties at therapeutic concentrations by consistently decreasing pro- inflammatory cytokines. Clomipramine could be a good candidate to counteract SARS-CoV-2 infection worsening thanks to its high penetration in the brain and its anti-inflammatory effects.
    
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- Properties
  - Categories
    
    Ligands of Transporters
    
    Alternative Name
    
    Clomipramine hydrochloride; 3-Chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride; Chlorimipramine hy drochloride
    
    CAS Number
    
    17321-77-6
    
    Molecular Formula
    
    C19H24Cl2N2
    
    Molecular Weight
    
    351.31 g/mol
    
    MDL Number
    
    MFCD00069234
    
    Note
    
    There is a hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Baumeister et al. (2015). Childhood trauma and adulthood inflammation: A meta-analysis of peripheral C-reactive protein, Interleukin-6 and Tumour Necrosis Factor-α. Molecular Psychiatry 21(5): 642–649.
    Nobile et al. (2020). Clomipramine Could Be Useful in Preventing Neurological Complications of SARS-CoV-2. Infection Journal of Neuroimmune Pharmacology 15:347–348.