Pomalidomide (CC-4047)

- Overview
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    Background
    
    Pomalidomide, previously known as CC-4047 or actimid, is a potent immunomodulatory molecule that exhibits antineoplastic activity for the treatment of hematological malignancies, especially relapsed and refractory multiple myeloma (MM). As a derivative of thalidomide, pomalidomide has a similar chemical structure as thalidomide except for the addition of two oxo groups in the phthaloyl ring and an amino group at the fourth position. Generally, as an immunomodulatory molecule, pomalidomide demonstrates antitumor activity through a mechanism of blocking the tumor microenvironment by modulation of tumor-supporting cytokines (TNF-α, IL-6, IL-8 and VEGF), directly down-regulating key functions of tumor cells, and engaging support from non-immune host cells.
    
    Reference:
    AA Chanan-Khan, A Swaika, A Paulus, SK Kumar, JR Mikhael, SV Rajkumar, A Dispenzieri, and MQ Lacy. Pomalidomide: the new immunomodulatory agent for the treatment of multiple myeloma. Blood Cancer Journal (2013) 3, el43
    Evangelos Terpos, Nikolaos Kanellias, Dimitrios Christoulas, Efstathios Kastritis, and Meletios A Dimopoulos. Pomalidomide: a novel drug to treat relapsed and refractory multiple myeloma. Onco Targets Ther 2013; 6: 531-538
- Properties
  - Categories
    
    Immunomodulator, antumor/anti-angiogenic
    
    Alternative Name
    
    Actimid,4-Aminothalidomide,CC 4047
    
    CAS Number
    
    19171-19-8
    
    Molecular Formula
    
    C13H11N3O4
    
    Molecular Weight
    
    273.2
    
    Appearance
    
    A solid
    
    Purity
    
    98.60%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥7.5 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N
    
    * For Research Use Only
- Reference
  - 1. Guo R, Jiang C, et al. "MYC Controls the Epstein-Barr Virus Lytic Switch." Mol Cell. 2020;78(4):653-669.e8. PMID:32315601