AqT™ Antibody SN38 Conjugate Evaluation Kit

The AqueaTether™ (AqT™) antibody SN38 conjugate evaluation kit is one of the few ADC kits currently available for customers to perform conjugations in-house and evaluate the benefit of AqT™ linkers for ADC on a small scale. The kit uses SN38 modified with a super-hydrophilic, water-soluble, and charge neutral AqueaTether™ (AqT™) linker to improve its water solubility and decrease its non-specific interactions with neighboring drugs after conjugation. The end result is an ADC with exceptionally high loading with no or minimum aggregation.

SN38 is loaded onto the antibody through an amide bond via the surface amines of the antibody. After AqT™ ADC reaches the target, the hydrophilic AqT™ linker can be separated from SN38 via its releasable ester bond. This tactic (traceless release) allows: 1) efficient transportation of the ADC in the biological media with minimum aggregation and toxicity, 2) preservation of the bystander killer effect of SN38.

The kit is configured for labeling either one 1 mg (Cat#: CM81380.1) or 3 mg (Cat#: CM81380) antibody sample.

• Key Features of this AqT™ ADC evaluation kit
Proprietary super-hydrophilic and water-soluble linkage
High loading with average 5 to 7 SN38 per antibody with minimal added aggregation
Sugar alcohol-based AqT™ linker preserves the properties of the antibody
Releasable linkage with fully released SN38 (traceless release) to maximize the efficacy
Fast and easy preparation: 4 hr preparation and <1 hr hands-on time

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