Anti-CDK4 antibody

Overview
- CDK4 is a major catalytic subunit of mammalian D‐type cyclins. The gene for cdk4 is localized to human chromosome 12q13. The cdk4 protein is constitutively expressed throughout the cell cycle and it is the assembly and accumulation of functional cdk4/cyclin D complexes which is rate limiting for the progression through the G1 phase of the cell cycle. Once the complex is formed it must be activated by the phosphorylation of threonine 172 on the cdk4 subunit, a reaction mediated by a cdk‐activating kinase (CAK). Complex formation and phosphorylation are independently regulated events. The phosphorylation of the cdk4 subunit is subject to regulation of both stimulatory and inhibitory cytokine signals thereby allowing cdk4 to function as a mid G1 checkpoint. CDK4 gene is amplified in well differentiated liposarcoma.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG2 alpha
  
  Reactivity
  
  human
  
  Clone
  
  DCS‐31
  
  Immunogen
  
  Full length CDK4 of human origin.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Cyclin-Dependent Kinase 4; Cell Division Protein Kinase 4; Psk-J3 (Gene ID:1019; UniProt:P11802)
  
  * For research use only