Cdc42 G-LISA Activation Assay (Colorimetric format) - 24 assays

Zi, Jingjing et al. PFN1 Inhibits Myogenesis of Bovine Myoblast Cells via Cdc42-PAK/JNK. Cells. 2022
Jiang, Ruiwei et al. CDC42 governs normal oviduct multiciliogenesis through activating AKT to ensure timely embryo transport. Cell Death & Disease 2022 13:9. 2022
Meng, Zhipeng et al. The Hippo pathway mediates Semaphorin signaling. Science Advances. 2022
Merlin, Johanna et al. Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation. Nature Metabolism. 2021
Ma, Yuanyuan et al. Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development. Development (Cambridge). 2021
Vallejo, Daniela et al. Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neurons. Journal of Neurochemistry. 2021
Wurzer, Hannah et al. Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling. Frontiers in Immunology. 2021
Jozic, Ivan et al. Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds. Communications Biology. 2021
Salameh, Joëlle et al. Cdc42 and its BORG2 and BORG3 effectors control the subcellular localization of septins between actin stress fibers and microtubules. Current Biology. 2021
Lee, Daniel. miR‑769‑5p is associated with prostate cancer recurrence and modulates proliferation and apoptosis of cancer cells. Experimental and Therapeutic Medicine. 2021
Novak, Caymen M. et al. Compressive stimulation enhances ovarian cancer proliferation, invasion, chemoresistance, and mechanotransduction via cdc42 in a 3d bioreactor. Cancers. 2020
Andrews, Madeline G. et al. Mtor signaling regulates the morphology and migration of outer radial glia in developing human cortex. eLife. 2020
Reyes-Miguel, Tania et al. CDC42 drives RHOA activity and actin polymerization during capacitation. Reproduction. 2020
Wilson, Kitchener D. et al. Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates. Developmental Cell. 2020
Wu, Huijuan et al. Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells. Cell. 2020
Zhang, Xiao et al. Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration. JCI Insight. 2020
Malek, Natalia et al. Knockout of ACTB and ACTG1 with CRISPR/Cas9(D10A) technique shows that non-muscle β and γ actin are not equal in relation to human melanoma cells’ motility and focal adhesion formation. International Journal of Molecular Sciences. 2020
Choraghe, Rohan P. et al. RHOA-mediated mechanical force generation through Dectin-1. Journal of cell science. 2020
Ursino, Gloria M et al. ABCA12 regulates insulin secretion from β‐cells. EMBO reports. 2020
Gorisse, Laetitia et al. Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42. Journal of Biological Chemistry. 2020
Rong, Zhouyi et al. Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models. FASEB Journal. 2020
Talamás-Lara, Daniel et al. Entamoeba histolytica and Entamoeba dispar: Morphological and Behavioral Differences Induced by Fibronectin through GTPases Activation and Actin-Binding Proteins. The Journal of eukaryotic microbiology. 2020
Krueger, Irena et al. Reelin amplifies glycoprotein VI activation and alphaiib beta3 integrin outside-in signaling via PLC Gamma 2 and Rho GTPases. Arteriosclerosis, Thrombosis, and Vascular Biology. 2020
Wu, Xuping et al. Wnt5a induces ROR1 and ROR2 to activate RhoA in esophageal squamous cell carcinoma cells. Cancer Management and Research. 2019
Zanin, Juan P. et al. The p75NTR influences cerebellar circuit development and adult behavior via regulation of cell cycle duration of granule cell progenitors. Journal of Neuroscience. 2019
Yan, Ting et al. Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells. Journal of Biological Chemistry. 2018
Santhana Kumar, Karthiga et al. TGF-β Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma. Cell Reports. 2018
Veluthakal, Rajakrishnan et al. Restoration of glucose-stimulated Cdc42-PAK1 activation and insulin secretion by a selective Epac activator in type 2 diabetic human islets. Diabetes. 2018
Mayer, Louisa et al. Nbeal2 interacts with Dock7, Sec16a, and Vac14. Blood. 2018
Suraneni, Praveen K. et al. Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity. Blood Advances. 2018
Kim, Jongshin et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. Journal of Clinical Investigation. 2017
Ruggiero, Carmen et al. Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion. Science Signaling. 2017
Gu, Changkyu et al. Dynamin autonomously regulates podocyte focal adhesion maturation. Journal of the American Society of Nephrology. 2017
Jones, Eleanor L. et al. Dendritic Cell Migration and Antigen Presentation Are Coordinated by the Opposing Functions of the Tetraspanins CD82 and CD37. The Journal of Immunology. 2016
Sroka, Jolanta et al. Lamellipodia and membrane blebs drive efficient electrotactic migration of rat walker carcinosarcoma cells WC 256. PLoS ONE. 2016
Herrera-Martínez, Mayra et al. Antiamoebic activity of Adenophyllum aurantium (L.) strother and its effect on the actin cytoskeleton of Entamoeba histolytica. Frontiers in Pharmacology. 2016
Martins, Rui et al. Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions. Nature Immunology. 2016
Xiao, Bin et al. Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling. Oncotarget. 2016
Zhao, Chen Ze et al. Inhibition of farnesyl pyrophosphate synthase improves pressure overload induced chronic cardiac remodeling. Scientific Reports. 2016
Tien, Sui Chih et al. The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42. Nature Communications. 2016
Breslin, Jerome W. et al. Involvement of local lamellipodia in endothelial barrier function. PLoS ONE. 2015
Guo, Yuna et al. A novel pharmacologic activity of ketorolac for therapeutic benefit in ovarian cancer patients. Clinical Cancer Research. 2015
Yan, Yi et al. Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5. Nature Communications. 2015
Ochoa-Alvarez, Jhon A. et al. Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms. Oncotarget. 2015
Hanin, Geula et al. Competing targets of microRNA-608 affect anxiety and hypertension. Human Molecular Genetics. 2014
Rigano, Luciano A. et al. Listeria monocytogenes antagonizes the human GTPase Cdc42 to promote bacterial spread. Cellular Microbiology. 2014
Chakravarti, Bandana et al. Thioaryl naphthylmethanone oxime ether analogs as novel anticancer agents. Journal of Medicinal Chemistry. 2014
Ahn, Bum Ju et al. Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics. Journal of Biological Chemistry. 2014
Kalia, Manjula et al. Japanese Encephalitis Virus Infects Neuronal Cells through a Clathrin-Independent Endocytic Mechanism. Journal of Virology. 2013
Barrio, Laura et al. TLR4 Signaling Shapes B Cell Dynamics via MyD88-Dependent Pathways and Rac GTPases. The Journal of Immunology. 2013
Valtcheva, Nadejda et al. The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. Journal of Biological Chemistry. 2013
Dubash, Adi D. et al. The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1. Journal of Cell Biology. 2013
Ramsay, Alan G. et al. Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenali******. Blood. 2013
Yao, Honghong et al. Nonmuscle myosin light-chain kinase mediates microglial migration induced by HIV Tat: involvement of β1 integrins. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013
Chen, Bin et al. Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fraction. Cellular Physiology and Biochemistry. 2013
Bray, Kristi et al. Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration. Breast Cancer Research. 2013
Yang, Jian et al. Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice. Cardiovascular Research. 2013
Dhaliwal, Anandika et al. Cellular Cytoskeleton Dynamics Modulates Non-Viral Gene Delivery through RhoGTPases. 2012
Chen, Guang et al. Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells (Journal of Biological Chemistry (2012) 2. Journal of Biological Chemistry. 2012
Chen, Si Meng et al. Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTOR. Biochemical Pharmacology. 2012
Martin-Granados, Cristina et al. A role for PP1/NIPP1 in steering migration of human cancer cells. PLoS ONE. 2012
Elali, Ayman et al. Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells. Brain Pathology. 2012
Eggers, Carrie M. et al. STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells. The Journal of biological chemistry. 2012
Ramsay, Alan G. et al. Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenali******: Establishing a reversible immune evasion mechanism in human cancer. Blood. 2012
Lichtenstein, Mathieu P. et al. Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives. Journal of Alzheimer's disease : JAD. 2010
Stankiewicz, Traci E. et al. GTPase activating protein function of p85 facilitates uptake and recycling of the β1 integrin. Biochemical and biophysical research communications. 2010
Romero, Ana M. et al. Chronic ethanol exposure alters the levels, assembly, and cellular organization of the actin cytoskeleton and microtubules in hippocampal neurons in primary culture. Toxicological Sciences. 2010
McHenry, Peter R. et al. P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. Breast Cancer Research. 2010
Heckman-Stoddard, Brandy M. et al. Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression. 2009
Schlegel, Nicolas et al. Impaired cAMP and Rac 1 signaling contribute to TNF-alpha-induced endothelial barrier breakdown in microvascular endothelium. Microcirculation (New York, N.Y. : 1994). 2009