Antimycin

- Overview
  - Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit. Antimycin A is widely used as a bioprobe of respiration and other applications with over 5,000 literature citations.
    
    Antimycin A is soluble in ethanol, methanol, DMF and DMSO.
    
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    Background
    
    Antimycin A binds to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone.
- Properties
  - CAS Number
    
    1397-94-0
    
    Molecular Formula
    
    C28H40N2O9 (for A1)
    
    Molecular Weight
    
    548.6 (for A1)
    
    Appearance
    
    White solid
    
    Storage
    
    -20°C
    
    * For research use only