Anti-STAT6 antibody

Overview
- Signal Transducer and Activator of Transcription 6 (STAT6) is a transcription factor in the Jak/STAT signal transduction pathway responsible for mediating IL‐4 immune signaling. STAT6 was recently suggested to be a reliable marker to distinguish solitary fibrous tumors from other soft tissue neoplasms. Gene fusions are common in solitary fibrous tumors. Recent next generation sequencing studies demonstrated the presence of a NAB2‐STAT6 fusion, formed by an intrachromosomal inversion fusing two neighboring genes on chromosome 12q13, in 55‐100% of solitary fibrous tumors, regardless of tumor morphology or anatomical site. By immunohistochemistry, nuclear STAT6 expression can discriminate solitary fibrous tumors from its morphological mimics in the meninges, including meningioma, glioblastoma, gliosarcoma, hemangioblastoma, schwannoma and hemangioma. STAT6 antibody was observed expression in all solitary fibrous tumors (54/54) tested, regardless of histology, anatomical site or CD34 status. Morphological mimics of solitary fibrous tumors were negative, demonstrating 100% specificity.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Clone
  
  EP325
  
  Immunogen
  
  A peptide mapping at the C‐terminus of STAT6 of human origin
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Signal Transducer And Activator Of Transcription 6; Il-4 Stat (Gene ID:6778; UniProt:P42226)
  
  * For research use only