Spironolactone

- Overview
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    Background
    
    Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.
- Properties
  - Categories
    
    Competitive mineralocorticoid (aldosterone) receptor antagonist
    
    Alternative Name
    
    S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate
    
    CAS Number
    
    52-01-7
    
    Molecular Formula
    
    C24H32O4S
    
    Molecular Weight
    
    416.57
    
    Appearance
    
    A solid
    
    Purity
    
    99.65%
    
    Solubility
    
    insoluble in H2O; ≥16.23 mg/mL in EtOH; ≥18 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(=O)SC1CC2=CC(=O)CCC2(C3C1C4CCC5(C4(CC3)C)CCC(=O)O5)C
    
    * For Research Use Only
- Reference
  - 1. Shaj K, Hutcherson RJ, et al. "ATR Kinase Activity Limits Mutagenesis and Promotes the Clonogenic Survival of Quiescent Human Keratinocytes Exposed to UVB Radiation." Photochem Photobiol. 2019 Sep 25. PMID:31554014
    2. KAVYA SHAJ. "DIFFERING FUNCTIONS OF ATR KINASE IN HUMAN EPIDERMAL KERATINOCYTES EXPOSED TO ULTRAVIOLET B RADIATION." Wright State University. 2019.
    3. Kemp MG. "DNA damage-induced ATR kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor II-H (TFIIH)." J Biol Chem. 2017 Jun 7. pii: jbc.M117.788406. PMID:28592488