RhoA Pull-down Activation Assay Biochem Kit (bead pull-down format) - 20 Assays

Spel, Lotte et al. CDC42 regulates PYRIN inflammasome assembly. Cell Reports. 2022
Almarán, Beatriz et al. Rnd3 Is a Crucial Mediator of the Invasive Phenotype of Glioblastoma Cells Downstream of Receptor Tyrosine Kinase Signalling. Cells. 2022
Zheng, Cankun et al. CX3CL1 Worsens Cardiorenal Dysfunction and Serves as a Therapeutic Target of Canagliflozin for Cardiorenal Syndrome. Frontiers in Pharmacology. 2022
Soda, Tomohiro et al. Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach. Scientific Reports. 2022
Kholmanskikh, Stanislav et al. Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1. Scientific Reports 2022 12:1. 2022
Xu, Weiyi et al. Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity. Molecular Biology of the Cell. 2022
Loria, Rossella et al. SEMA6A/RhoA/YAP axis mediates tumor-stroma interactions and prevents response to dual BRAF/MEK inhibition in BRAF-mutant melanoma. Journal of Experimental and Clinical Cancer Research. 2022
Soda, Tomohiro et al. Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach. Scientific Reports 2022 12:1. 2022
Qian, Zhanyang et al. Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury. International Journal of Biological Sciences. 2022
Shin, Yuna et al. NPFFR2 Contributes to the Malignancy of Hepatocellular Carcinoma Development by Activating RhoA/YAP Signaling. Cancers. 2022
Mahly, Adnan et al. Anillin governs mitotic rounding during early epidermal development. BMC Biology. 2022
Swiatlowska, Pamela et al. Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching. Science Advances. 2022
Yokoyama, Yusuke et al. Crumbs3 is expressed in oral squamous cell carcinomas and promotes cell migration and proliferation by affecting RhoA activity. Oncology Letters. 2022
Usuki, Seigo et al. Konjac Ceramide (kCer)-Mediated Signal Transduction of the Sema3A Pathway Promotes HaCaT Keratinocyte Differentiation. Biology. 2022
Vittoria, Marc A. et al. Inactivation of the Hippo tumor suppressor pathway promotes melanoma. Nature Communications 2022 13:1. 2022
Rackow, Ashley R. et al. The Novel Small Molecule BTB Inhibits Pro-Fibrotic Fibroblast Behavior though Inhibition of RhoA Activity. International Journal of Molecular Sciences. 2022
Hamuro, Junji et al. Repressed miR-34a Expression Dictates the Cell Fate to Corneal Endothelium Failure. Investigative Ophthalmology & Visual Science. 2022
Seetharaman, Shailaja et al. Microtubules tune mechanosensitive cell responses. Nature Materials. 2022
Lee, Jiyoung et al. Role of MCP-1 and IL-8 in viral anterior uveitis, and contractility and fibrogenic activity of trabecular meshwork cells. Scientific Reports. 2021
Miao, Chunhui et al. An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli. Nature Communications. 2021
Guo, Shuyu et al. Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development. Theranostics. 2021
Wang, Junyi et al. Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA. Cell Death and Disease. 2021
Zhan, Fangbiao et al. RhoA enhances osteosarcoma resistance to MPPa-PDT via the Hippo/YAP signaling pathway. Cell and Bioscience. 2021
Chen, Lei et al. The adenosine A2A receptor alleviates postoperative delirium-like behaviors by restoring blood cerebrospinal barrier permeability in rats. Journal of Neurochemistry. 2021
Ko, Eunsun et al. Nrf2 regulates cell motility through RhoA–ROCK1 signalling in non-small-cell lung cancer cells. Scientific Reports. 2021
Nishiyama, Kanako et al. CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP. Life Science Alliance. 2021
Sharma, Pawan et al. Diacylglycerol kinase inhibition reduces airway contraction by negative feedback regulation of gq-signaling. American Journal of Respiratory Cell and Molecular Biology. 2021
Agbaegbu Iweka, Chinyere et al. The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules. Journal of Neurochemistry. 2021
De Belly, Henry et al. Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate. Cell Stem Cell. 2021
Rolle, Irene Giulia et al. Heart failure impairs the mechanotransduction properties of human cardiac pericytes. Journal of Molecular and Cellular Cardiology. 2021
Wang, Ying et al. Murine epsins play an integral role in podocyte function. Journal of the American Society of Nephrology. 2020
Wee, Kenneth et al. Snail induces epithelial cell extrusion by regulating RhoA contractile signalling and cell–matrix adhesion. Journal of Cell Science. 2020
Wang, Xiaobo et al. Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis. Cell Metabolism. 2020
Hellinger, Johanna W. et al. Identification of drivers of breast cancer invasion by secretome analysis: insight into CTGF signaling. Scientific Reports. 2020
Kitchen, Gareth B. et al. The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia. Proceedings of the National Academy of Sciences of the United States of America. 2020
Wang, Ruixiao et al. Rac1 silencing, NSC23766 and EHT1864 reduce growth and actin organization of bladder smooth muscle cells. Life Sciences. 2020
Moodley, Serisha et al. RET isoform-specific interaction with scaffold protein Ezrin promotes cell migration and chemotaxis in lung adenocarcinoma. Lung cancer (Amsterdam, Netherlands). 2020
Kumagai, Shogo et al. An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells. Immunity. 2020
Barabutis, Nektarios et al. Protective mechanism of the selective vasopressin V1A receptor agonist selepressin against endothelial barrier dysfunction. Journal of Pharmacology and Experimental Therapeutics. 2020
Wang, Qinglian et al. Thymol alleviates AGEs-induced podocyte injury by a pleiotropic effect via NF-κB-mediated by RhoA/ROCK signalling pathway. Cell Adhesion and Migration. 2020
Guo, Yaxiu et al. Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC. FASEB Journal. 2020
Ramírez-Ramírez, Danelia et al. Rac1 is necessary for capacitation and acrosome reaction in guinea pig spermatozoa. Journal of cellular biochemistry. 2020
Grun, Daniel et al. NRP-1 interacts with GIPC1 and SYX to activate p38 MAPK signaling and cancer stem cell survival. Molecular Carcinogenesis. 2019
Akula, Murali K. et al. Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions. Nature Communications. 2019
Schipper, Koen et al. Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin. Nature Communications. 2019
Jiao, Yi et al. Mechanism of H2S‑mediated ROCK inhibition of total flavones of Rhododendra against myocardial ischemia injury. Experimental and Therapeutic Medicine. 2019
Tanga, Naomi et al. The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice. Glia. 2019
Yu, Minhao et al. Increased proton-sensing receptor GPR4 signalling promotes colorectal cancer progression by activating the hippo pathway. EBioMedicine. 2019
Lee, Sung Kyoung et al. Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity. Cell Reports. 2018
Cai, Jing et al. A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease. Genes and Development. 2018
Zhang, Xin et al. Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2. Cell Death and Disease. 2018
Ma, Teng jiao et al. CLOCK and BMAL1 stabilize and activate RHOA to promote F-actin formation in cancer cells. Experimental and Molecular Medicine. 2018
Brauer, Philip R. et al. Krüppel-like factor 4 mediates cellular migration and invasion by altering RhoA activity. Cell Communication and Adhesion. 2018
Zhang, Lei et al. Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation. Cellular Physiology and Biochemistry. 2018
Lehman, Heather L. et al. NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation. Oncotarget. 2018
Haemmerle, Monika et al. Platelets reduce anoikis and promote metastasis by activating YAP1 signaling. Nature Communications. 2017
Goodman, Linda et al. Integrin α8 and Pcdh15 act as a complex to regulate cilia biogenesis in sensory cells. Journal of Cell Science. 2017
Xue, Li et al. Duration of simulated microgravity affects the differentiation of mesenchymal stem cells. Molecular Medicine Reports. 2017
Islam, Salman Ul et al. PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transition. Oncotarget. 2017
Cho, Soo Young et al. Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers. Gastroenterology. 2017
Watts, Bruns A. et al. High-mobility group box 1 inhibits HCO3_ absorption in the medullary thick ascending limb through RAGE-rho-ROCK-mediated inhibition of basolateral Na+/H+ exchange. American Journal of Physiology - Renal Physiology. 2016
Gilbert, James et al. The X-linked autism protein KIAA2022/KIDLIA regulates neurite outgrowth via N-cadherin and δ-catenin signaling. eNeuro. 2016
Priya, Rashmi et al. Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions. Nature Cell Biology. 2015
Wang, Y. et al. Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864. British Journal of Pharmacology. 2015
Du, Chang Qing et al. Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced fibrotic responses in vascular smooth muscle cells. International Journal of Molecular Medicine. 2015
Parker, William H. et al. Intracellular sscorbate prevents endothelial barrier permeabilization by thrombin. Journal of Biological Chemistry. 2015
Inoue-Mochita, Miyuki et al. P38 MAP kinase inhibitor suppresses transforming growth factor-β2-induced type 1 collagen production in trabecular meshwork cells. PLoS ONE. 2015
Wang, Shi Jie et al. CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells. Oncotarget. 2015
Su, Chien Chia et al. Phenotypes of trypsin- and collagenase-prepared bovine corneal endothelial cells in the presence of a selective rho kinase inhibitor, Y-27632. Molecular Vision. 2015
Stankiewicz, Trisha R. et al. Rho family GTPases: Key players in neuronal development, neuronal survival, and neurodegeneration. Frontiers in Cellular Neuroscience. 2014
Yan, Chao et al. Discovery and characterization of small molecules that target the GTPase Ral. 2014
Xie, Xi et al. Activation of RhoA/ROCK regulates NF-κB signaling pathway in experimental diabetic nephropathy. Molecular and cellular endocrinology. 2013
Zhan, Hong et al. The effect of an NgR1 antagonist on the neuroprotection of cortical axons after cortical infarction in rats. Neurochemical Research. 2013
Hara, Yusuke et al. Directional migration of leading-edge mesoderm generates physical forces: Implication in Xenopus notochord formation during gastrulation. Developmental Biology. 2013
Xu, Jie et al. RhoGAPs Attenuate Cell Proliferation by Direct Interaction with p53 Tetramerization Domain. Cell Reports. 2013
Tsuboi, Naoko et al. The effect of monocyte chemoattractant protein-1/CC chemokine ligand 2 on aqueous humor outflow facility. Investigative Ophthalmology and Visual Science. 2012
Nithipatikom, Kasem et al. Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells. Endocrinology. 2012
Lee, Wonhwa et al. Barrier protective effects of withaferin A in HMGB1-induced inflammatory responses in both cellular and animal models. Toxicology and applied pharmacology. 2012
Dong, Ming et al. Increased Rho kinase activity in congestive heart failure. European Journal of Heart Failure. 2012
Cheng, Haoran et al. Infrasonic noise induces axonal degeneration of cultured neurons via a Ca²⁺ influx pathway. Toxicology letters. 2012
Gastonguay, Adam et al. The role of Rac1 in the regulation of NF-kB activity, cell proliferation, and cell migration in non-small cell lung carcinoma. Cancer Biology & Therapy. 2012
Li, B. et al. RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells. Oncogene. 2012
Eitaki, Masato et al. Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells. BMC Cancer. 2012
Borah, Sapan et al. The Rho1 GTPase-activating protein CgBem2 is required for survival of azole stress in Candida glabrata. Journal of Biological Chemistry. 2011
Khan, Omar M. et al. Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice. Journal of Clinical Investigation. 2011
Balanis, Nikolas et al. β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells. Molecular Biology of the Cell. 2011
Hu, Yi et al. Effects of ischemic preconditioning on vascular reactivity and calcium sensitivity after hemorrhagic shock and their relationship to the RhoA–Rho-kinase pathway in rats. Journal of cardiovascular pharmacology. 2011
Du, Hui et al. Phenylephrine induces elevated RhoA activation and smooth muscle α-actin expression in Pkd2+/-vascular smooth muscle cells. Hypertension Research. 2010
Xing, Dongmei et al. Effect of cAMP on TGFβ1-induced corneal keratocyte-myofibroblast transformation. Investigative Ophthalmology and Visual Science. 2009
Xing, Dongmei et al. Hypoxia reduces TGFβ1-induced corneal keratocyte myofibroblast transformation. Molecular Vision. 2009
Ríos, Amelia et al. Participation of Rho, ROCK-2, and GAP activities during actin microfilament rearrangements in Entamoeba histolytica induced by fibronectin signaling. Cell Biology International. 2008
Cheng, Zhi Jie et al. Distinct mechanisms of clathrin-independent endocytosis have unique sphingolipid requirements. Molecular Biology of the Cell. 2006
Pixley, Fiona J. et al. BCL6 suppresses RhoA activity to alter macrophage morphology and motility. Journal of cell science. 2005
Sasai, Noriaki et al. The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements. 2004
Birukova, Anna A. et al. Protein kinase A attenuates endothelial cell barrier dysfunction induced by microtubule disassembly. American journal of physiology. Lung cellular and molecular physiology. 2004
Cetin, Selma et al. Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions. The Journal of biological chemistry. 2004
Yang, Seun Ah et al. Rho and Rho-kinase mediate thrombin-induced phosphatidylinositol 4-phosphate 5-kinase trafficking in platelets. Journal of Biological Chemistry. 2004
Orr, Anthony Wayne et al. Thrombospondin Induces RhoA Inactivation through FAK-dependent Signaling to Stimulate Focal Adhesion Disassembly. Journal of Biological Chemistry. 2004
Setiadi, Hendra et al. Signal-dependent distribution of cell surface P-selectin in clathrin-coated pits affects leukocyte rolling under flow. Journal of Cell Biology. 2003
. Activation of RhoA in Alcohol-Induced Intestinal Barrier Dysfunction | Request PDF.