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Overview
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Threonine356/Threonine359 (T356/T359) is a major phosphorylation site of the somatostatin receptor 2 (SST2). The pT356/pT359-SST2 antibody detects phosphorylation in response to high-efficacy agonists such as octreotide and low-efficacy agonists such as pasireotide. T356/T359 phosphorylation is a key regulator of SST2 desensitization, β-arrestin recruitment and internalization. The pT356/pT359-SST2 antibody can detect phosphorylated SST2 in mouse tissues in vivo. The pT356/pT359-SST2 antibody can be used for detection of the subcellular location of phosphorylated SST2 by immunocytochemistry.
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Overview