o-Phenanthroline

- Overview
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    Background
    
    O-Phenanthroline is a membrane-permeable metal chelator, known as a non-specific matrix metalloproteinase (MMP) inhibitor [1].
    Matrix metalloproteinases (MMPs) are zinc-dependent proteases involved in intra- and extra-cellular matrix remodeling resulting from an oxidative stress injury to the heart, of which MMP-2 increases during myocardial ischemia-reperfusion (I/R) injury-reduced oxidative stress, proteolyzing nuclear structural proteins.
    In vitro proteolysis of lamins, which are the intermediate filament proteins providing support to the nuclear structural proteins and are targets of MMP-2, o-Phenanthroline abolished the proteolysis of lamin A [2].
    The isolated rat hearts were subjected to ischemia-reperfusion (I/R) injury, of which treated with o-Phenanthroline had better left ventricular developed pressure and coronary flow during the reperfusion phase compared to those did not receive the drug [2].
    
    [1] Georgi N, Landman E B M, Klein T J, et al. O-Phenanthroline as modulator of the hypoxic and catabolic response in cartilage tissue-engineering models [J]. J Tissue Eng Regen Med. 2017, 11(3): 724-732.
    [2] Baghirova S, Hughes B G, Poirier M, et al. Nuclear matrix metalloproteinase-2 in the cardiomyocyte and the ischemic-reperfused heart [J]. J Mol Cell Cardiol. 2016, 94: 153-161.
- Properties
  - Alternative Name
    
    1,10-phenanthroline
    
    CAS Number
    
    66-71-7
    
    Molecular Formula
    
    C12H8N2
    
    Molecular Weight
    
    180.21
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥360.42 mg/mL in DMSO; ≥58.9 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

o-Phenanthroline

Background

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