MemGlow™ NR4A Membrane Polarity Probe

MemGlow NR4A is a solvatochromic photostable plasma membrane-targeting dye with on/off switching that has been optimized for Super Resolution Point Accumulation for Imaging in Nanoscale Topography (SR-PAINT). Upon binding with a plasma membrane in a predominant liquid ordered (LO) phase NR4A exhibits a 45-50 nm wavelength shift relative to liquid disordered (Ld) phase enabling investigators to examine the nanoscale distribution of local chemical polarity in plasma membranes.

NR4A Membrane Polarity Probe Product Functions (MG06)
• The NR4A Membrane Polarity Probe is the first probe that enables nanoscale cartography of the lipid order exclusively at the surface of live cells.
• The NR4A Membrane Polarity Probe reveals nanoscopic protrusions and invaginations of lower Lipid Order in Plasma Membranes
• High Specificity helps unveil rich nanoscale structural features of the plasma membrane
• Weak Binders allow for better tracking of turn on events thanks to continuous flow exchange between the probe and membrane

** 2 nmol of MemGlow will produce a 20µM stock solution when reconstituted with 100 µl of anhydrous DMSO

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