Budesonide

- Overview
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    Background
    
    Budesonide is an anti-inflammatory corticosteroid [1].Budesonide has shown the potent glucocorticoid activity and little mineralocorticoid activity. In addition, Budesonide has been reported to have a wide range of inhibitory activities against multiple cells types and mediators involved in allergic and nonallergic-mediated inflammatory. Besides, the anti-inflammatory action of budesonide has been revealed to contribute to the efficacy in asthma. Apart from these, orally inhaled budesonide has been found to be rapidly absorbed in the lungs and that peak concentration is typically reached within 20 minutes. The results have been exhibited that peak plasma concentration is achieved in about 1 to 2 h and the absolute systemic availability is 6%-13% after oral administration of budesonide [1].
    
    [1] Ricardo Zollner1*, Eduardo Abib Junior1,2*, Luciana Fernandes Duarte2, Maurício Wesley Perroud2andAntonioRicardo Amarante2. Bioequivalency Study for Inhaled Drugs: A Pharmacodynamic Approac. Bioequivalence & Bioavailability
- Properties
  - Categories
    
    Anti-inflammatory corticosteroid
    
    Alternative Name
    
    (6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a-dimethyl-10-propyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one
    
    CAS Number
    
    51333-22-3
    
    Molecular Formula
    
    C25H34O6
    
    Molecular Weight
    
    430.53
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥18.13 mg/mL in EtOH; ≥20.2 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C(C([H])([H])O[H])[[email protected]@]12OC(C([H])([H])C([H])([H])C([H])([H])[H])([H])O[[email protected]]1([H])C([H])([H])[[email protected]]([[email protected]@](C([H])([H])C3([H])[H])([H])[[email protected]@]4([H])[[email protected]@](C([H])([H])[H])(C([H])=C5[H])C3=C([H])C5=O)([H])[[email protected]]2(C([H])([H])[H])C([H])([H])[[email protected]]4([H])O[H]
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Budesonide

Background

Documents

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