Betamethasone

- Overview
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    Background
    
    Betamethasone is a synthetic corticosteroid and agonist of glucocorticoid receptor [1].Betamethasone has shown the inflammatory response by the betamethasone-receptor complex modulated the activity of certain genes, altering the production and activity of proteins. These proteins include phospholipase A2, cyclooxygenase-2 and NO-synthase. Betamethasone has been reported to inhibit the expression of these enzymes results in reduced production of such inflammatory mediators as prostaglandins, leukotrienes and nitric oxide. In addition betamethasone has also revealed to inhibit keratinocyte proliferation [1].
    
    [1] Pharmacology Review(s)-FDA.http://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021852s000_PharmR.pdf
- Properties
  - Categories
    
    Glucocorticoid receptor agonist
    
    Alternative Name
    
    (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
    
    CAS Number
    
    378-44-9
    
    Molecular Formula
    
    C22H29FO5
    
    Molecular Weight
    
    392.46
    
    Appearance
    
    A solid
    
    Purity
    
    99.65%
    
    Solubility
    
    insoluble in H2O; ≥19.6 mg/mL in DMSO; ≥4.37 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
    
    * For Research Use Only