Atomoxetine HCl

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Atomoxetine HCl is a selective norepinephrine transporter inhibitor (Ki= 5 nM) Norepinephrine transporter is a multi-pass membrane protein that is essential for norepinephrine reuptake into presynaptic nerve terminals and regulates norepinephrine homeostasis. Atomoxetine blocked coupling of radioligands to clonal cell lines that transfected with human norepinephrine transporter, serotonin and dopamine transporters with Ki= 5, 77 and 1451 nM respectively. [1] In microdialysis studies in rat, atomoxetine increases extracellular levels of norepinephrine transporter in prefrontal cortex 3-fold without altering 5-HTEX levels. Atomoxetine also increases DAEX concentrations in PFC 3-fold without altering DAEX in striatum or nucleus accumbens. Comparing with methylphenidate, atomoxetine do not increase DA in striatum or nucleus accumbens, indicating it would not have motoric or drug abuse liabilities. [1]
- Properties
  - Alternative Name
    
    (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine;hydrochloride
    
    CAS Number
    
    82248-59-7
    
    Molecular Formula
    
    C17H22ClNO
    
    Molecular Weight
    
    291.82
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥14.35 mg/mL in DMSO; ≥2.94 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Atomoxetine HCl

Background

We Also Recommend

BRL-54443

Desvenlafaxine Succinate