Filgiant® Sterilizing-grade Hydrophobic Filters
Sterilizing-grade hydrophobic filters are the core components used in industrial fields such as pharmaceuticals, biotechnology, food and beverage, and electronics to ensure the sterile state of gases and specific liquids. The most used material for hydrophobic sterilizing-grade filtration membranes is polytetrafluoroethylene (PTFE), which has extremely low surface energy and exhibits outstanding hydrophobic properties. Additionally, PTFE has strong chemical inertness and can withstand strong acids, strong bases, various organic solvents, and corrosive chemicals. This enables PTFE to be used for filtering corrosive non-aqueous liquids. The strong hydrophobic property makes filters an ideal choice for gas filtration. In humid air or steam environments, the filter membrane would not be wetted by condensation water and clogged, thus ensuring the stable flow of gases.
Filgiant® PTFE Sterilizing-grade Hydrophobic Filters
Amerigo Scientific offers Filgiant® sterilizing-grade hydrophobic filters, which are composed of single-layer or double-layer polytetrafluoroethylene (PTFE) membranes and polypropylene components. These filters possess excellent chemical compatibility and characteristics such as high flow rate, high flux, and no fiber shedding. Various filter sizes and connectors are available to meet extensive usage requirements.
| Product | Nominal Size |
|---|---|
| Filgiant® Sterilizing-grade Hydrophobic Capsule Filter, 1 inch Size | 1 inch |
| Filgiant® Sterilizing-grade Hydrophobic Capsule Filter, 2.5-20 inch Size | 2.5 inch; 5 inch; 10 inch; 20 inch |
| Filgiant® Sterilizing-grade Hydrophobic Cartridge Filter | 2.5 inch; 5 inch; 10 inch; 20 inch; 30 inch |
| Filgiant® Sterilizing-grade Hydrophobic Disk Filter | dia. 50mm |
Product Features
- The filter membrane made of PTFE, withstanding multiple sterilization cycles;
- Retaining particles of size down to 0.01μm though physical retention and charge adsorption;
- High-temperature and high-pressure tolerance;
- Good chemical compatibility, pH 1-14 tolerance;
- Suitable for the scale ranging from R&D to manufacture
Filter Applications
- Vent filters for storage tanks, fermentation tanks, and WFI tanks;
- Gas sterile filtration of compressed air/clean pipelines;
- Sterile filtration of input/output gases in bioreactors;
- Sterile filtration of non-aqueous liquids
Product Parameters
| Filter type | Disk Filter | Capsule Filter | Cartridge Filter | |
| Single layer/Double layer | Single layer/Double layer | Single layer/Double layer | ||
| Nominal size | Φ50mm | 1/2.5/5/10/20 inch | 2.5/5/10/20/30 inch | |
| Membrane pore size | 0.22μm/0.22+0.22μm | |||
| Effective filtration area | 13.8cm² | 0.04/0.16/0.33/0.65/1.3m² | 0.16/0.33/0.65/1.3/1.95m² | |
| Filter components and structure | Filter membrane | Hydrophobic Polytetrafluoroethylene (PTFE) | ||
| Support layer | Polypropylene (PP) | |||
| Housing/structural components | Polypropylene (PP) | |||
| Vent O-ring | Silicone | Silicone | -- | |
| O-ring | -- | -- | Silicone/EPDM/FKM | |
| Maximum operating differential pressure | Forward:5.5bar (80psi) at 25°C; 1.7 bar (25psi) at 80°C | Forward:5.5bar (80psi) at 25°C; 1.7 bar (25psi) at 80°C | Forward:5.5bar (80psi) at 25°C; 1.7 bar (25psi) at 80°C | |
| Reverse:2.1bar (30psi) at 25°C | Reverse:2.1bar (30psi) at 25°C | Reverse:2.1bar (30psi) at 25°C | ||
| Maximum inlet pressure | -- | 0.65Mpa | -- | |
| Bubble point | ≥1100mbar (100%, IPA bubble point at 25°C) | |||
| Water intrusion (at 2500mbar) | 2.5 inch:≤0.2ml/min; 5 inch:≤0.4ml/min; 10 inch:≤0.8ml/min; 20 inch:≤1.6ml/min | |||
| Sterilization resistance | Offline: 126 °C /60 minutes, 3 times | Offline :126°C/30 minutes, 30 times (SIP not allowed) | Offline :126°C/60 minutes, 50 times SIP: Forward :142°C/30 minutes, 200 times Reverse :126°C/60 minutes, 25 times (not exceeding the maximum operating pressure difference of cartridge) |
|
| Cleanliness | Complying with 21CFR21 0.3(b)(6) of "None fiber release" | |||
| Bacterial endotoxin | ≤ 0.25 EU/ml | |||
| Biosafety test | All materials of the filter element meet USP <88> , Class VI -70°C biosafety evaluation of plastic materials | |||
| Bacteria retention | The bacterial retention rate of products was tested according to the test method of ASTMF838 and with the defective Pseudomonas (ATCC19146), and the minimum retention rate was 107cfu/cm². | |||
| Aerosol test | The retention rate for Brevundimonas diminuta (ATCC 19146) aerosol was tested referring to the requirements of PDA TR40, and the minimum retention rate was 107cfu/cm². | |||
Pressure Drop and Gas Flowrate
Figure 1. Filgiant® Hydrophobic Gas Filter (0.22μm) - Pressure Drop and Gas Flowrate
Related Products
SaiPress® Sterilizing-grade Hydrophilic Filters
Amerigo Scientific offers SaiPress® PES hydrophilic filters with high flux and high capacity and SaiPress® PVDF hydrophilic filters with high porosity and low protein adsorption. A variety of specifications are available to meet different requirements of sterilization filtration for liquids.
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