The DIANT® LiFT – High Throughput Nanoparticle Manufacturing

The DIANT® LiFT is our commercial lipid nanoparticle production system, which can scale-up processes from our benchtop DIANT® LARU system for the continuous production of lipid and polymer-based liquid-injectable nanoparticle pharmaceutical products. With inline dilution, drug loading, and nanoparticle modification, the LiFT's continuous processing offers extensive benefits over traditional batch processing.

As the exclusive distributor of the NanoFlowSizer™ in the United States, DIANT's systems work with InProcess-LSP's unique particle size analyzer technology to non-invasively characterize nanoparticles inline.

Download Product Datasheet

Cat. No.	Specification	Unit	Price	Quantity
NPS1527213-01	Max Output Flow: 400 ml/min	Each	Inquiry

Cat. No.

Specification

Unit

Price

Quantity

NPS1527213-01

Max Output Flow: 400 ml/min

Each

Inquiry

Product Description

Product Description

DIANT® LiFT Add-Ons and Continuous Processing Systems
Optional add-ons that are available for the DIANT® LiFT include:
· Customized PAT integration
· Particle size analyzer
· pH monitor/probes
· Conductivity
· Temperature control – Control the temperature of your sample at each stage with the water circulator, sold separately

DIANT® LiFT + IEM
The DIANT® IEM is a continuous processing system for the controlled modification of pre-formed vesicular nanoparticles:
· Intravesicular aqueous modifications – small molecules like liposomes can be actively loaded to promote drug encapsulation
· Extravesicular surface modifications – capabilities include adding polymeric coating and active drug moieties

The IEM system can:
Perform one or several simultaneous nanoparticle modifications as a continuous process
PEGylate particles, including LNPs, polymeric micelles, and others
Decorate particles
Manage growth kinetics
· Salt loading for liposomes
· Surface deposition for LNPs
Perform PAT – inline UV-Vis with model prediction (optional & customizable)
Sense pressure, conductivity, and temperature
Perform inline heat exchange and mixing
Perform inline bioburden reduction filtration at collection
Perform inline, single-pass concentration

Specifications

DIANT® Jet technology for high throughput
Continuous particle size analysis through Process Analytical Technology (PAT)
· Integrated, inline particle size control and monitoring with InProcess-LSP
· NanoFlowSizer™, SR-DLS
· Automatic particle size control
· Real-time particle monitoring
· Fast response (~6 seconds per measurement)
Hybrid or integrated system
Explosion-proof-rated design
Capacity options from 0.8 LPM to:
· DIANT® LiFT – 2 LPM maximum
· DIANT® LiFT HP – 20 LPM maximum
21 CFR-compliant software
Continuous or batch operation
Commercial GMP-compliant manufacturing of lipid nanoparticles (LNPs), liposomes, nucleic acid/lipid complexes, polymeric micelles, suspensions, and emulsions