The DIANT® LARU Discovery – Research LNP Processing

The DIANT® LARU Discovery is a low flow rate, low dead volume system for research nanoparticle processing. Featuring patented turbulent jet technology, the DIANT® LARU Discovery enables lowest volume research test runs for multi-mode specification and optimization of nanoparticle processing. The LARU Discovery processing technology can be scaled with DIANT® system product offerings from clinic to commercial scale.

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Cat. No.	Specification	Unit	Price	Quantity
NPS1527212-01	Minimum Collection Volume: 2-3 mL (per run)	Each	Inquiry

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Product Description

Product Description

Solvent Injection
The LARU Discovery features DIANT® Jet technology, a patented single-jet, low flow rate, low dead volume (LDV) solvent injection system for high throughput. Used in all DIANT® systems to facilitate seamless scale-up from R&D to commercial manufacturing, DIANT® Jet technology precisely combines genetic material/API in buffer with lipids in solvents.

Features

· With other DIANT solutions, scalable from R&D to commercial cGMP manufacturing
· Enables a direct translation to continuous nanoparticle processing
· Produces nanoparticles of various sizes: ~25 d.nm to >500 d.nm
· Collects volumes as low as 2 mL (per run)
· Has standard connections for bottles, tubes, or 2D bags for ease of use

Specifications

Minimum Collection Volume: 2-3 mL (per run)
Solvent Flow Rate: 20 mL/min (nominal)
Flow Rate Ratio: 2-8
E1/A1 Pump Type: Syringe
Dilution Pump Type: Peristaltic (enables 0-350 mL/min dilution rates)
Operating Temperature Range: 15-30 degrees C
Power Requirements: 110/220 VAC, 200 W max.

Applications

Application Description

The LARU Discovery is a research-scale system that can continuously produce lipid nanoparticles (LNPs), liposomes, nucleic acid/lipid complexes, polymeric micelles, and suspensions.