WiScan Hermes High Content Imaging System
| Cat. No. | Description | Specification | Unit | Price | Quantity |
|---|---|---|---|---|---|
| LCIS531082-01 | Easily generate publication-quality images at high throughput speeds | Bright field: Transmission white LED | Each | Inquiry |
|
Product Description
Product Description
·Versatile
Whether you are performing assay development, compound screens, transfection assays or looking at a few samples in great detail, and whether you are using 3D models (such as spheroids, Organoids), Zebrafish imaging, primary cells, fixed cells or live cell imaging, WiScan® Hermes is the solution for you.
·Reliable
WiScan Hermes, automated imaging system for high content screening (HCS) provides the unique combination of the two contradicting primary functions of automated microscopy: Image quality and acquisition speed.
·Robust
WiScan® Hermes' mechanisms are based on patents, creatively designed to meet heavy duty operation demands (24/7) with full process robustness.
·Flexible
WiScan® Hermes is a cost-effective system that is both sophisticated and flexible, offering 7 fluorescence colors, bright field option, and a large range of air objectives. The system can accommodate a variety of multi-well plates and sample formats (slides, dishes…) and offers environmental control for live cell assays.
·Intuitive
It doesn't matter if you are a beginner or an experienced microscopist, Hermes easily allows you to look deeper into your samples. The system is intuitively operated. Its built-in applications are extremely easy to use, and are operated at the push-of-a-button.
·Automated immersion media scanning
Now, for the first time, a high-content imaging system can utilize oil immersion objectives for automating high resolution cell biology applications. Samples in a multi-well plate format can be scanned in their entirety, unsupervised and with no user intervention. The system can accommodate a variety of multi-well plates and sample formats and offers environmental control for live cell assays.
Utilizing high NA oil objectives also enables fully automated super-resolution imaging.
Whether you are performing assay development, compound screens, transfection assays or looking at a few samples in great detail, and whether you are using 3D models (such as spheroids, Organoids), Zebrafish imaging, primary cells, fixed cells or live cell imaging, WiScan® Hermes is the solution for you.
·Reliable
WiScan Hermes, automated imaging system for high content screening (HCS) provides the unique combination of the two contradicting primary functions of automated microscopy: Image quality and acquisition speed.
·Robust
WiScan® Hermes' mechanisms are based on patents, creatively designed to meet heavy duty operation demands (24/7) with full process robustness.
·Flexible
WiScan® Hermes is a cost-effective system that is both sophisticated and flexible, offering 7 fluorescence colors, bright field option, and a large range of air objectives. The system can accommodate a variety of multi-well plates and sample formats (slides, dishes…) and offers environmental control for live cell assays.
·Intuitive
It doesn't matter if you are a beginner or an experienced microscopist, Hermes easily allows you to look deeper into your samples. The system is intuitively operated. Its built-in applications are extremely easy to use, and are operated at the push-of-a-button.
·Automated immersion media scanning
Now, for the first time, a high-content imaging system can utilize oil immersion objectives for automating high resolution cell biology applications. Samples in a multi-well plate format can be scanned in their entirety, unsupervised and with no user intervention. The system can accommodate a variety of multi-well plates and sample formats and offers environmental control for live cell assays.
Utilizing high NA oil objectives also enables fully automated super-resolution imaging.
Features
Automated immersion media scanning
Now, for the first time, a high-content imaging system can utilize oil immersion objectives for automating high resolution cell biology applications. Samples in a multi-well plate format can be scanned in their entirety, unsupervised and with no user intervention. The system can accommodate a variety of multi-well plates and sample formats and offers environmental control for live cell assays.
Utilizing high NA oil objectives also enables fully automated super-resolution imaging.
Full automation, No Compromises
· Unique hardware automatically adds immersion oil to objectives
· No user intervention; No oil spilling
· Autonomous, rapid image acquisition for:
– Full-plate scanning
– Time-lapse imaging of live cells
· Optimized autofocus, X, Y, Z motion and long-duration oil capsules for easy maintenance
Now, for the first time, a high-content imaging system can utilize oil immersion objectives for automating high resolution cell biology applications. Samples in a multi-well plate format can be scanned in their entirety, unsupervised and with no user intervention. The system can accommodate a variety of multi-well plates and sample formats and offers environmental control for live cell assays.
Utilizing high NA oil objectives also enables fully automated super-resolution imaging.
Full automation, No Compromises
· Unique hardware automatically adds immersion oil to objectives
· No user intervention; No oil spilling
· Autonomous, rapid image acquisition for:
– Full-plate scanning
– Time-lapse imaging of live cells
· Optimized autofocus, X, Y, Z motion and long-duration oil capsules for easy maintenance
Product Details
Certifications
CE, UL
Specifications
3D reader: EPI-fluorescence inverted optics mounted on XYZ (patented) linear scanner
Auto Focus: Patented ultra-fast laser-based Auto Focus with 100nm resolution
XY motion: Accurate positioning with 200nm repeatability
Illumination sources: Hermes Real-time observer includes 4 fluorescence channels DAPI, GFP, RFP, CY5.
Up to 7 optional LED sources are available in other Hermes models (DAPI, CFP, GFP, YFP, RFP, mCherry, CY5).
Transmission: White LED source
Optical Filters: 2 emission filters and compatible dichroic filters (automatically exchanged)
Objectives (Air): Choice of air objectives in the range: 2X to 60X, high NA.
Oil/ Water immersion objectives: Option to add automated immersion media to allow use of immersion objectives (oil/water) – optional hardware upgrade.
Camera: High sensitivity CMOS camera with 5.1MPixel resolution
Sample format: Supports full-area screening of 6-1536 well plates Supports slides, microarrays, 35 mm dish formats. U-shaped bottom plats are optional. Flexible and simple interface for introducing new sample formats to the microscope.
IT: PC with Windows® operating system and touch screen. Joystick for microscope navigation.
Enclosure: Allows operation in fully lit areas
Desktop standalone platform: 47 W x 72 D x 57 H (cm), 18.5 W x 28.5 D x 22.4 H (inches) With plate cover closed.
Certification: CE, UL
Live cell imaging: Allow long time lapse experiments. Sample does not move during most of the scanning process.
Live cell conditions
Temperature control: Ranges from ambient+5°C to 40°C ±0.5°C
CO2 level control: Enables setting of 0.02 L/min - 0.13 L/min mixed with air for desired CO2 percentage. (external accessory). CO2 Range: 0-15%. Set Point Resolution: 1%
Humidity
Object mapping for rare events detection
First scan: rapid scan of entire plate with low magnification, for efficient region of interest object mapping.
Second scan: re-visitng solely detected objects with high magnification
Analysis tools: WiSoft® based image processing tools for object definition and detection in the first low magnification scan and further tools to analyze the detected objects with high magnification
Objectives: Automatic objective exchanger, accommodates of up to 3 objectives at a time
Throughput: Enhances the throughput of high magnification scanning of rare objects
Statistical tools: Provides automatic decision resulting in efficient screening for minimum required objects in a well
Combination of HCS and HTS: Ultra-fast High Content Screening unit
Image acquisition speed >10 images per second (depends on experiment conditions)
Throughput / Acquisition speed: A full 96-well plate screening using 10X magnification with a single field per well, four fluorescence colors, 50ms exposure time per channel, runs in ~2 minutes. With some applications, this will include data processing and analysis results simultaneously with image acquisition.
Automation Remote accessibility: Protocols (applications and screening parameters) execution and management
External loader compatibility to 3rd-party robotics (Robot/manipulator)
Communication channel for control by external equipment
Loading door with automatic opening/closing synchronized with external equipment
External loader (Robot/manipulator) integration: Full integration supported
DAPI/HOCHEST: Ex.: 390/18; Em.: 440/40
CFP: Ex.: 435/40; Em.: 482/35
FITC/GFP: Ex.: 482/25; Em.: 525/30
YFP: Ex.: 510/20; Em.: 542/27
TRITC/RFP/Cy3: Ex.: 559/34; Em.: 607/36
mCherry: Ex.: 580/23; Em.: 624/40
Cy5: Ex.: 650/13; Em.: 694/44
Hermes system incorporates an automated objective exchanger which holds up to 3 objectives at a time.
Hermes supports air objectives and can optionally support a unique immersion media dispensing to allow oil/water immersion objectives.
Objectives selection:
Auto Focus: Patented ultra-fast laser-based Auto Focus with 100nm resolution
XY motion: Accurate positioning with 200nm repeatability
Illumination sources: Hermes Real-time observer includes 4 fluorescence channels DAPI, GFP, RFP, CY5.
Up to 7 optional LED sources are available in other Hermes models (DAPI, CFP, GFP, YFP, RFP, mCherry, CY5).
Transmission: White LED source
Optical Filters: 2 emission filters and compatible dichroic filters (automatically exchanged)
Objectives (Air): Choice of air objectives in the range: 2X to 60X, high NA.
Oil/ Water immersion objectives: Option to add automated immersion media to allow use of immersion objectives (oil/water) – optional hardware upgrade.
Camera: High sensitivity CMOS camera with 5.1MPixel resolution
Sample format: Supports full-area screening of 6-1536 well plates Supports slides, microarrays, 35 mm dish formats. U-shaped bottom plats are optional. Flexible and simple interface for introducing new sample formats to the microscope.
IT: PC with Windows® operating system and touch screen. Joystick for microscope navigation.
Enclosure: Allows operation in fully lit areas
Desktop standalone platform: 47 W x 72 D x 57 H (cm), 18.5 W x 28.5 D x 22.4 H (inches) With plate cover closed.
Certification: CE, UL
Live cell imaging: Allow long time lapse experiments. Sample does not move during most of the scanning process.
Live cell conditions
Temperature control: Ranges from ambient+5°C to 40°C ±0.5°C
CO2 level control: Enables setting of 0.02 L/min - 0.13 L/min mixed with air for desired CO2 percentage. (external accessory). CO2 Range: 0-15%. Set Point Resolution: 1%
Humidity
Object mapping for rare events detection
First scan: rapid scan of entire plate with low magnification, for efficient region of interest object mapping.
Second scan: re-visitng solely detected objects with high magnification
Analysis tools: WiSoft® based image processing tools for object definition and detection in the first low magnification scan and further tools to analyze the detected objects with high magnification
Objectives: Automatic objective exchanger, accommodates of up to 3 objectives at a time
Throughput: Enhances the throughput of high magnification scanning of rare objects
Statistical tools: Provides automatic decision resulting in efficient screening for minimum required objects in a well
Combination of HCS and HTS: Ultra-fast High Content Screening unit
Image acquisition speed >10 images per second (depends on experiment conditions)
Throughput / Acquisition speed: A full 96-well plate screening using 10X magnification with a single field per well, four fluorescence colors, 50ms exposure time per channel, runs in ~2 minutes. With some applications, this will include data processing and analysis results simultaneously with image acquisition.
Automation Remote accessibility: Protocols (applications and screening parameters) execution and management
External loader compatibility to 3rd-party robotics (Robot/manipulator)
Communication channel for control by external equipment
Loading door with automatic opening/closing synchronized with external equipment
External loader (Robot/manipulator) integration: Full integration supported
DAPI/HOCHEST: Ex.: 390/18; Em.: 440/40
CFP: Ex.: 435/40; Em.: 482/35
FITC/GFP: Ex.: 482/25; Em.: 525/30
YFP: Ex.: 510/20; Em.: 542/27
TRITC/RFP/Cy3: Ex.: 559/34; Em.: 607/36
mCherry: Ex.: 580/23; Em.: 624/40
Cy5: Ex.: 650/13; Em.: 694/44
Hermes system incorporates an automated objective exchanger which holds up to 3 objectives at a time.
Hermes supports air objectives and can optionally support a unique immersion media dispensing to allow oil/water immersion objectives.
Objectives selection:
Magnification | N.A. | µm/pixel | Working Distance [µm] | Imm. Media |
2X | 0.08 | 3.0 | 6200 | Air |
4X | 0.16 | 1.5 | 13000 | Air |
10X | 0.40 | 0.6 | 3100 | Air |
20X | 0.45 | 0.3 | 6600-7800 | Air |
20X | 0.80 | 0.3 | 600 | Air |
40X | 0.60 | 0.15 | 2700-4000 | Air |
40X | 0.75 | 0.15 | 510 | Air |
40X | 0.90 | 0.15 | 200 | Air |
60X | 0.95 | 0.1 | 200 | Air |
40X | 1.4 | 0.15 | 130 | Oil |
60X | 1.42 | 0.1 | 150 | Oil |
100X | 1.45 | 0.065 | 130 | Oil |
20X | 0.7 | 0.3 | 350 | Water |
40X | 1.15 | 0.15 | 250 | Water |
60X | 1.2 | 0.1 | 280 | Water |
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