Sterilizing-grade Capsule Filters

LeSiever Sterilizing-grade Capsule Filters contain an asymmetric hydrophilic PES membrane that offers the greatest assurance of filtration performance, stability and service life for sterilization, prefiltration and clarification of low to high-contaminant liquids. The product provides effective bioburden reduction and particulate control of different process streams.

LeSiever SF Sterilizing-grade PES capsule filters are available in double layer 0.45/0.2 µm and single layer 0.2 µm PES membrane, and multiple configurations that vary by filtration area and type of inlet/outlet connection.

LeSiever Sterilizing-grade Capsule Filter with 0.45/0.2µm PES
For double layer filters, they are the final 0.2 µm membrane layer which ensures sterility of the filtrate, while pre-filter layer can improve the capacity of the filter. 0.45 and 0.2 µm heterogeneous double layer sterilizing PES membrane can be used for plasma proteins, serum, vaccines and process intermediates.

LeSiever Sterilizing-grade Capsule Filters with 0.2µm PES
0.2 µm single layer sterilizing PES membrane is particle-free liquids such as buffer, cell and tissue culture media, media additives, pharmaceutical water.

· High flow-rates associated with low differential pressure
· Integrity testable using the forward flow and bubble point test
· Gamma-irradiatable, autoclavable or available pre-sterilized
· Choice of connection options
· Identified by a lot number and unique serial number for complete traceability

LeSiever Sterile-grade capsules are used in R&D, pilot and production applications, including processes such as cell and tissue culture media, microbial growth media, additives, active ingredients, buffers, formulations, plasma proteins, serum, vaccines, and pharmaceutical water.

· Single-use bioreactor inlet and off-gas
· Sterile tank venting
· Fermentation air venting
· Sterile process gases
· Air filtration in the fill-finish