Monomix Core

Cat. No.	Specification	Unit	Price	Quantity
CC02501820-01	Monomix Core 500 (60 µm, 500 Å),	Each	Inquiry
CC02501820-02	Monomix Core 1000 (60 µm, 1000 Å),	Each	Inquiry

Cat. No.

Specification

Unit

Price

Quantity

CC02501820-01

Monomix Core 500 (60 µm, 500 Å),

Each

Inquiry

CC02501820-02

Monomix Core 1000 (60 µm, 1000 Å),

Each

Inquiry

Product Description

Product Description

Monomix Core chromatographic media, is a novel polymeric chromatographic medium with a core-shell(s) hierarchical layer structure, a narrow size distribution, and desired porous structure, which combines a size exclusion separation and various binding chemistries. The shell layer of Monomix Core is modified with hydrophilic groups, which effectively enhances the hydrophilicity of the separation medium, and then minimizes the nonspecific binding (NSB) of biomolecules.

Features

• Key chromatographic features such as bead size, bead size uniformity, shell thickness and its uniformity, porous structure, functional group density in both shell layer and core layer, etc. can be consistently controlled and optimized to meet separation and purification challenges of various biomolecules.
• A systematic platform solution for new biologics in any stage from analytical characterization to production, and from small scale to full scale production.
• High capture capacity using flow-through mode.
• Excellent bead surface hydrophilicity, negligible nonspecific binding (NSB) to biomolecules, and excellent biocompatibility.
• Robust mechanical stability, excellent tolerance to high pressure and high flow rate.
• Can withstand higher flow rates when compared with traditional agarose-based multimodal chromatographic media.
• High resolution, high column efficiency, and high recovery.
• Excellent batch to batch repeatability & reproducibility.
• Scalable.
• Minor bed volume change under common column packing conditions.
• Customization with new features, such as mild CIP condition, etc. is available upon request.
• Secure supply chain of raw materials.

Specifications

Matrix: Polymeric based
Volume average particle diameter D50 (µm): 60 ± 10, tunable upon request
Particle size distribution D90/ D10: ≤1.5, mono-sized
Average pore size, protein cut off MW: Monomix Core 1000: 1000 Å, 700 kD; Monomix Core 500: 500 Å, 400 kD
Shell thickness uniformity: Good
Variance in volume ratio of core/shell distribution among resins: Small. Monodispersed beads, easy to precisely control
Surface chemistry of shell layer: Hydrophilic functional groups
Surface chemistry of core layer: Amine
Ion exchange capacity of core layer (µmol Cl-/mL medium): 80-300
Maximum linear flow rate: 1000 cm/h
Operation temperature: ≤ 40 °C
pH stability: 2-13
Operation pressure limit: ≤ 1 Mpa (10 bar)
Mobile phase compatibility: All commonly used aqueous buffers, such as 1 M NaOH, 6 M guanidine hydrochloride, 30% IPA and 70% EtOH
Long-term storing condition: 20% EtOH
CIP conditions: 1 M NaOH in aqueous solution, or 1 M NaOH in 30% IPA aqueous solution