Monomix™ Aminodiol - Affinity Chromatography

Cat. No.	Description	Specification	Unit	Price
CC02501923-01	One fixed endpiece and one adjustable endpiece	6.6x150 mm Column, Bed Height 4-12 cm, Volume 1.4-4.1mL	Each	Inquiry
CC02501923-02	One fixed endpiece and one adjustable endpiece	6.6x250 mm Column, Bed Height 14-22 cm, Volume 4.8-7.5mL	Each	Inquiry
CC02501923-03	One fixed endpiece and one adjustable endpiece	10.0x150 mm Column, Bed Height 4-12 cm, Volume 3.1-9.4mL	Each	Inquiry
CC02501923-04	One fixed endpiece and one adjustable endpiece	10.0x250 mm Column, Bed Height 14-22 cm, Volume 19.63mL	Each	Inquiry
CC02501923-05	One fixed endpiece and one adjustable endpiece	15.0x150 mm Column, Bed Height 4-12 cm, Volume 7.1-21.2mL	Each	Inquiry
CC02501923-06	One fixed endpiece and one adjustable endpiece	15.0x250 mm Column, Bed Height 14-22 cm, Volume 24.7-38.9mL	Each	Inquiry
CC02501923-07	One fixed endpiece and one adjustable endpiece	25.0x150 mm Column, Bed Height 4-12 cm, Volume 19.6-58.9mL	Each	Inquiry
CC02501923-08	One fixed endpiece and one adjustable endpiece	25.0x250 mm Column, Bed Height 14-22 cm, Volume 68.7-108.0mL	Each	Inquiry
CC02501923-09	One fixed endpiece and one adjustable endpiece	35.0x400 mm Column, Bed Height 29-37 cm, Volume 279.0-355.9mL	Each	Inquiry
CC02501923-10	One fixed endpiece and one adjustable endpiece	50.0x150 mm Column, Bed Height 4-12 cm, Volume 77.5-235.0mL	Each	Inquiry
CC02501923-11	One fixed endpiece and one adjustable endpiece	50.0x400 mm Column, Bed Height 29-37 cm, Volume 580.7-741.0mL	Each	Inquiry
CC02501923-12	One fixed endpiece and one adjustable endpiece	50.0x500 mm Column, Bed Height 39-47 cm, Volume 781.0-941.2mL	Each	Inquiry
CC02501923-13	Non-adjustable with two fixed endpieces	6.6x150 mm Column, Bed Height 12 cm, Volume 4.1mL	Each	Inquiry
CC02501923-14	Two adjustable endpieces	6.6x250 mm Column, Bed Height 6-22 cm, Volume 2.1-7.5mL	Each	Inquiry
CC02501923-15	Two adjustable endpieces	6.6x400 mm Column, Bed Height 21-37 cm, Volume 7.2-12.7mL	Each	Inquiry
CC02501923-16	Two adjustable endpieces	10.0x250 mm Column, Bed Height 6-22 cm, Volume 3.1-17.3mL	Each	Inquiry
CC02501923-17	Two adjustable endpieces	15.0x250 mm Column, Bed Height 6-22 cm, Volume 10.6-38.9mL	Each	Inquiry
CC02501923-18	Two adjustable endpieces	25.0x250 mm Column, Bed Height 6-22 cm, Volume 29.4-108.0mL	Each	Inquiry
CC02501923-19	Two adjustable endpieces	50.0x250 mm Column, Bed Height 5.8-22.0 cm, Volume 120.2-440.7mL	Each	Inquiry
CC02501923-20	Two adjustable endpieces	50.0x400 mm Column, Bed Height 21-37 cm, Volume 420.5-741.0mL	Each	Inquiry
CC02501923-21	Two adjustable endpieces	50.0x500 mm Column, Bed Height 31-47 cm, Volume 620.8-941.2mL	Each	Inquiry

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Product Description

Product Description

Monomix MC30-Aminodiol Affinity Resin: 30 μm narrowly dispersed polymethacrylate rigid base bead is functionalized with a polyhydroxylated surface coating layer that provides a bio-inert surface and shows low non-specific binding to biomolecules. Aminodiol group is then conjugated to bead surface through an innovative method (patent pending). The resulting affinity resin is applicable for the isolation and purification of boron-containing molecules including large biomolecules.

Monomix MC30-Aminodiol affinity resin and column fill gaps in existing purification technologies and cover both analytical market needs and industrial purification market needs. The key benefits are higher separation efficiency, higher purification throughput, and overall lower purification cost compared with conventional RP, IEX, and recrystallization purification.

Features

• Specific binding to boron-containing molecules
• Provides efficient capture and release under mild and straight forward purification conditions, simplify subsequent purification steps and maximize overall production efficiency
• Decreases process development time and enhances productivity
• No need to use a lot of organic solvents. High biocompatibility, and can better maintain the biological activity of purified molecules
• Produce less chemical wastes (liquid and solid) which are easy to be treated. Reduce risk of safety and environmental pollution
• Chromatography medium and column can be cleaned and reused many times
• Excellent scalability. Provide prepacked analytical columns, semi-prep columns, prep columns and bulk loose resin
• Resin customization: can provide polymethyl methacrylate beads with 10, 15, 30 and 60 µm bead size and other matrix beads
• Innovative chromatography medium and column, enable a platform affinity chromatography technology for boron-containing molecules purification

Specifications

Resin Type: Monomix MC30-Aminodiol (30μm, 500Å/1000Å)
Base Matrix: Hydrophilic polymethacrylate
Average Bead Size D50 (µm): 30
Bead Size Distribution: D90/D10 ≤ 1.3
Average Pore Size (Å): 500, 1000
Functional Group: Aminodiol
Max Linear Flow Rate (cm/hr): 1000
Operating Temperature (°C): 4-40
pH Stability: 2-12
Operating Pressure (large ID column, preparative): ≤10 bar (1 MPa)
Operating Pressure (small ID column, preparative): ≤50 bar (5 MPa)
Mobile Phase Compatibility: Compatible with common salt buffers, organic/aqueous solutions (acetonitrile, ethanol, etc.), and common additives
Long Term Storage Store: in 20% ethanol aqueous solution, 2-25°C
CIP Condition: 0.5 M NaOH

Applications

Application Description

• Boron-containing molecules as proteasome inhibitor, for example, Bortezomib and Ixazomib
• Boron-containing boronic acid molecules as antifungal, antibacterial, and antiviral drugs. Tavaborole, Crisaborole and Vaborbactam
• Boron compounds and boron containing biomolecules used in Boron Neutron Capture Therapy (BNCT). Borofalan (Steboronine) and boron-containing acridine derivatives and antibody boron conjugates.
• Boron-containing compounds with thrombin inhibitory activity
• Boron containing intermediates used in organic chemistry synthesis which are very useful to introduce versatile
• functional groups. Boron compound used in boron selective reaction for molecular modular synthesis
• Chiral peptide separation. - C*-B- chiral carbon is next to a boron atom
• Used to recover unreacted or excess boron-containing reagents in chemical reactions. For example for a reaction between solid surfaces or polymers with soluble boron-containing reagents