VOR Bottom Stirred Bioreactor (50L-2000L)
Designed based on the mixing principle of conventional bioreactor;
Process equipment is free from cleaning and sterilization verification;
Slant stirring impeller reactor with low shearing force and dominating axial flow
Specification: 50L-2000L
Process equipment is free from cleaning and sterilization verification;
Slant stirring impeller reactor with low shearing force and dominating axial flow
Specification: 50L-2000L
| Cat. No. | Capacity | Unit | Price | Quantity |
|---|---|---|---|---|
| BAF1580466-01 | 50L | EA | Inquiry |
|
| BAF1580466-02 | 200L | EA | Inquiry |
|
| BAF1580466-03 | 500L | EA | Inquiry |
|
| BAF1580466-04 | 1000L | EA | Inquiry |
|
| BAF1580466-05 | 2000L | EA | Inquiry |
|
Product Description
Product Description
Both the mixed culture effect of traditional stirring and the superior performance of the process equipment free from cleaning and sterilization verification.
Bioreactor Tank Design
Stir
• Using a low shear force downward pressure stirring paddle to form an axial flow,
• Fully mixing the materials in the tank and keeping the cells in the culture system under the suspension status to enable the sufficient contact of cells and nutrient substances;
• The low shear force stirring paddle disperses the bottom bubbles and evenly distributes them into the culture medium,
• Improving the mass transfer efficiency between gas and liquid to meet the needs of cell culture.
Heating and Cooling
• Connect the PT1000 sensor with a doublelayer wall jacket and associate it with a TCU temperature control unit to ensure efficient heating, cooling, and uniformity of solution temperature. Provide temperature protection, over temperature alarm, and automatic stop of heating due to overheating.
Control Cabinet Design
• Control system adopts Siemens PLC, which works with sensor and hardware meeting cell culture requirements to form PID closed-loop control;
• 15" colour touch screen is used for local operation, flow and data display, dual data backup and has power-off protection function.
• The software system complies with the standards for computer system from development to GMP production phase and relevant requirements of GAMP5 and 21 CFR Part 11.
Dissolved oxygen (DO)
• Precisely positioned vent chassis offers two modes, coarse bubble and micro bubble. DO sensor may choose traditional optical electrode or disposable fibre optic electrode to realize real-time online monitoring and calibration and make flexible switching based process demands;
• Auto mode: Real-time control of DO value in the process; DO sensor links with Air, N₂ and O₂ mass flow controller and stirring speed to realize the closed-loop control and cumulant; the system would record their real-time flow and make statistics of the accumulated values.
• Manual mode: Air,N₂ and O₂ may be separately controlled by HMI; the system may record and count the real-time flow and accumulated values of Air,N₂ and O₂.
Pressure Protection
• If the pressure sensor exceeds the set value, the system automatically Close vent to ensure that the cell culture process maintains the proper pressure and avoids damage to the TOR reaction bag.
pH Monitoring
• pH sensor chooses traditional digital electrode to realize online monitoring and calibration in real time. Linked with acid and alkali pumps, pH sensor can realize pH value control in the process.
• Automatic mode: pH sensor is linked with acid and alkali pumps and CO₂ mass flow controller to realize closed-loop control and record cumulative acid and alkali flow.
• Manual mode: Acid pump, alkali pump, and CO₂ mass flow controller can be separately controlled by HMI.
Peristaltic Pump and Weighing
• Replenishing pump: Replenishing pump replenishes liquid to the reactor automatically;
• Auto mode: Replenishing pump may work with weighing device to realize closed-loop control; when set weight is reached, it stops automatically; the system would record and count the replenishing pump's accumulated values;
• Manual mode: Under manual mode, HMI may be used for control separately and the system would record and count the replenishing pump's accumulated values
Bioreactor Tank Design
Stir
• Using a low shear force downward pressure stirring paddle to form an axial flow,
• Fully mixing the materials in the tank and keeping the cells in the culture system under the suspension status to enable the sufficient contact of cells and nutrient substances;
• The low shear force stirring paddle disperses the bottom bubbles and evenly distributes them into the culture medium,
• Improving the mass transfer efficiency between gas and liquid to meet the needs of cell culture.
Heating and Cooling
• Connect the PT1000 sensor with a doublelayer wall jacket and associate it with a TCU temperature control unit to ensure efficient heating, cooling, and uniformity of solution temperature. Provide temperature protection, over temperature alarm, and automatic stop of heating due to overheating.
Control Cabinet Design
• Control system adopts Siemens PLC, which works with sensor and hardware meeting cell culture requirements to form PID closed-loop control;
• 15" colour touch screen is used for local operation, flow and data display, dual data backup and has power-off protection function.
• The software system complies with the standards for computer system from development to GMP production phase and relevant requirements of GAMP5 and 21 CFR Part 11.
Dissolved oxygen (DO)
• Precisely positioned vent chassis offers two modes, coarse bubble and micro bubble. DO sensor may choose traditional optical electrode or disposable fibre optic electrode to realize real-time online monitoring and calibration and make flexible switching based process demands;
• Auto mode: Real-time control of DO value in the process; DO sensor links with Air, N₂ and O₂ mass flow controller and stirring speed to realize the closed-loop control and cumulant; the system would record their real-time flow and make statistics of the accumulated values.
• Manual mode: Air,N₂ and O₂ may be separately controlled by HMI; the system may record and count the real-time flow and accumulated values of Air,N₂ and O₂.
Pressure Protection
• If the pressure sensor exceeds the set value, the system automatically Close vent to ensure that the cell culture process maintains the proper pressure and avoids damage to the TOR reaction bag.
pH Monitoring
• pH sensor chooses traditional digital electrode to realize online monitoring and calibration in real time. Linked with acid and alkali pumps, pH sensor can realize pH value control in the process.
• Automatic mode: pH sensor is linked with acid and alkali pumps and CO₂ mass flow controller to realize closed-loop control and record cumulative acid and alkali flow.
• Manual mode: Acid pump, alkali pump, and CO₂ mass flow controller can be separately controlled by HMI.
Peristaltic Pump and Weighing
• Replenishing pump: Replenishing pump replenishes liquid to the reactor automatically;
• Auto mode: Replenishing pump may work with weighing device to realize closed-loop control; when set weight is reached, it stops automatically; the system would record and count the replenishing pump's accumulated values;
• Manual mode: Under manual mode, HMI may be used for control separately and the system would record and count the replenishing pump's accumulated values
Features
• Hardware, software and consumables form an efficient, easy-to_x0002_use and powerful cell culture platform that supports cell growth, cell viability and metabolic process.
• Axial flow mixing and excellent material transfer effect
• Top quality accessories, stable run of system;
• Modular design, supporting customization
• Three-level authority, audit trail, complete electronic data reporting, easy transfer and storage
• The touch screen software control function is rich, simple and intuitive, and the feedback system logic is clear
• Coarse bubble and micro bubble combining top overlay aeration and disposable reaction bag bottom sparging aeration design
• Complete FAT, SAT, IQ/OQ files and services
• Axial flow mixing and excellent material transfer effect
• Top quality accessories, stable run of system;
• Modular design, supporting customization
• Three-level authority, audit trail, complete electronic data reporting, easy transfer and storage
• The touch screen software control function is rich, simple and intuitive, and the feedback system logic is clear
• Coarse bubble and micro bubble combining top overlay aeration and disposable reaction bag bottom sparging aeration design
• Complete FAT, SAT, IQ/OQ files and services
Specifications
Applications
Application Description
•Suspension cell culture;
•Adherent cell microcarrier culture;
•Process development;
•Process scale-up;
•Pilot test
•Inoculum amplification;
•GMP production.
•Adherent cell microcarrier culture;
•Process development;
•Process scale-up;
•Pilot test
•Inoculum amplification;
•GMP production.
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