Scissor N3 In Vitro Subcutaneous Injection Site Simulator

· Excipient screening during formulation development
· Formulation comparison
· Rank ordering formulations for candidate selection
· Investigation of drug stability upon and after injection

Gain biorelevant data about your subcutaneous sample in vitro
· Coupled with the Rainbow R6 in-situ fiber optic UV-vis spectrometer, lymphatic and systemic release data can be measured in-situ giving real-time results and enriching the data collection process.
· Sample aliquots can also be collected with an additional external fraction collector to allow for offline analysis with any preferred analytical method facilitating more in-depth research.

Extracellular matrices
· ECM
A hyaluronic acid-based viscous liquid dynamically created to mimic the human subcutaneous space for 24-hour long assays for immediate release formulations.‍
· ECM-XR
A hydrogel containing hyaluronic acid constructed to simulate the human subcutaneous space for up to a week aimed towards long-acting injectables for sustained release formulations.

· Understand in vitro how a drug behaves after subcutaneous injection and the impact this has on drug release with our Scissor N3.
· Reduce the reliance on inaccurate animal models and select formulation candidates with confidence based on bio-relevant information gained earlier in the development process, saving in both cost and time.
· The Scissor N3 mimics the stresses a biopharmaceutical experiences when transitioning from formulation conditions to a subcutaneous environment.
· Possible precipitation events can be monitored and correlated to lymphatic and systemic release dynamics quantified in the system.
· Scissor allows users to screen excipients and compare different formulations to identify the best candidates for further development.
· Compatible with an optional fraction collector

Injectable Formulation Delivery