CELL-WAV Automated Cell Expansion System

CELL-WAV series Automated Cell Expansion System consists of WAVE unit, control unit and compatible sterile consumables. It is mainly used for expansion and collection of stem cells, immune cells, and other cells required for cell therapy and cosmetology. The closed, automated culture system together with disposable consumables solve the risk of manual operation from the root and greatly improve cell viability and production efficiency.

Product Composition
1. WAVE unit
Gently heated rocker with dual trays can control temperature of small to large volume culture bags, touch screen can adjust and monitor weight, temperature, angle and speed, etc.
2.Gax mixer (integrated pH, DO sensor)
Provide gases of specific ratio (CO2, O2, air, N2) for the culture system, meeting different environmental requirements of cells.
3.Perfusion pump
Provide power for pumping liquid into and out of the culture bag, realizing automated control of sample-in, culture medium replenishment, waste-out and product harvest, etc.
4. Software control system
Operation software provides power supply and data communication to other modules, as well as features of parameter setting, calibration, operation curve, logging, etc, compliant with GMP requirements.
5.Disposable sterile cell culture bag
Compatible with CELL-WAV Automated Cell Expansion System, culture bags of different volumes have been tested for air tightness, toxicity and sterility, providing a closed and optimum environment for cell culture
The size and configuration can be freely matched according to customer's requirements to realize "bag to bag" seamless and sterile connection of the whole cell production process for 20mL-10L sample.
Basic culture bags, pH and DO optical culture bags and perfusion culture bags are applicable in different culture needs

Closed, bag-to-bag sterile connection.
Automated control liquids and gases.
Full culture process data monitoring (pH, DO, temperature, angle, speed, peristaltic pump, etc.)
High-density cell culture system-perfusion system.
Full operation, alarm, etc., can be recorded and tracked, compliant with FDA regulations.
Remote monitoring and operation.
Supporting customization, multi-specification cell bags available.

· Accurate temperature control and pH monitoring
CELL-WAV cell expansion system can reach the set temperature in about 30min, while an incubator may need 10h, cells can enter expansion stage fast; more stable temperature control and uniform heat transfer during culture process; pH fluctuates of ±0.2 shows stable cell culture environment.
· High cell expansion rate
CELL-WAVE cell expansion system has a higher cell expansion rate: it can reach 2 times of cell quantity in 5 days and 4 times in 9 days compared with manual culture; It supports higher cell density: up to 2*107/ml, saving medium and operation time (2~3 days); Cell viability is higher than manual culture and more stable.
· Effective cell expansion proportion
CELL-WAV cell expansion system can reach a higher proportion of CD3+ CD8+ double-positive cells (killer T cell) compared with manual culture.