Anti-VTCN1 Monoclonal Antibody - Amerigo Scientific

Subcat	Description	Isotype	Antibody Modification	Conjugate	Size	Price	Quantity
ASPR99	Anti-VTCN1 Antibody	Chicken IgY, Lambda		None		$680		Add

Anti-VTCN1 Monoclonal Antibody
- Product Description:
  
  The anti-VTCN1 antibody is a Chicken monoclonal antibody recommended for Western Blot, Blocking, Enzyme-Linked Immunosorbent Assay. This antibody specifically targets VTCN1 and demonstrates reactivity with human.
  
  Applications:
  
  Western Blot, Blocking, Enzyme-Linked Immunosorbent Assay
  
  Target:
  
  VTCN1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human VTCN1.
  
  Clonality:
  
  Monoclonal
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Preservative:
  
  Azide free
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-VTCN1 Monoclonal Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

VTCN1

Protein Name

V-Set Domain-Containing T-Cell Activation Inhibitor 1

Introduction

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative Names

VTCN1; B7X; VCTN1; B7 Family Member, H4; B7 Homolog 4; V-Set Domain Containing T Cell Activation Inhibitor 1; PRO1291; Immune Costimulatory Protein B7-H4; T-Cell Costimulatory Molecule B7x; B7 Family Member; H4; B7S1; T Cell Costimulatory Molecule B7x;

Gene ID

79679

UniProt

Q7Z7D3

Subcellular Location

Cell membrane

Tissue Specificity

Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.

Function

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

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