Anti-VTCN1 Monoclonal Antibody (A-2G6)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Size	Price	Quantity
ASZ1C1962	Anti-VTCN1 Antibody (A-2G6)	Mouse IgG		None		$460		Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASZ1C1962

Anti-VTCN1 Antibody (A-2G6)

Mouse IgG

None

$460

Add

Anti-VTCN1 Monoclonal Antibody (A-2G6)
- Product Description:
  
  The Anti-VTCN1 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human, mouse and rat VTCN1.
  
  Applications:
  
  Immunohistochemistry, Immunocytochemistry, Western Blot, Immunoprecipitation
  
  Source:
  
  Mouse
  
  Target:
  
  VTCN1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1).
  
  Immunogen:
  
  Recombinant VTCN1 protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  A-2G6
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  0.05% Proclin 300
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-VTCN1 Monoclonal Antibody (A-2G6) Applications
- Recommended Dilution:
  
  Western Blot: 0.01-2 µg/mL
  Immunohistochemistry: 5-20 µg/mL
  Immunocytochemistry: 5-20 µg/mL
  
  Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Protein Name

V-set domain-containing T-cell activation inhibitor 1

Introduction

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative Names

B7-H4; B7H4; B7S1; B7X; B7h.5; PRO1291; VCTN1

Gene ID

79679

UniProt

Q7Z7D3

Subcellular Location

Cell membrane

Tissue Specificity

Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.

Cell Line Specificity

Cancer enhanced

Function

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

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