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Anti-NTRK1 Monoclonal Antibody (15F10)
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Product Description:The Anti-NTRK1 antibody is a human monoclonal antibody recommended for use in ELISA, western blot, flow cytometry and other applications. This antibody specifically targets NTRK1 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Western Blot, Flow CytometryTarget:NTRK1Target Species:HumanSpecificity:This antibody reacts with human TrkA (Tyrosine kinase receptor of NGF).Clonality:MonoclonalClone ID:15F10Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-NTRK1 Monoclonal Antibody (15F10) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
NTRK1
Protein Name
High affinity nerve growth factor receptor
Introduction
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Alternative Names
Neurotrophic Receptor Tyrosine Kinase 1; Neurotrophic Tyrosine Kinase, Receptor, Type 1; High Affinity Nerve Growth Factor Receptor; TRK1-Transforming Tyrosine Kinase Protein; Tropomyosin-Related Kinase A; Tyrosine Kinase Receptor A; EC 2.7.10.1; P140-TrkA; Gp140trk; Trk-A
Gene ID
UniProt
Related Disease
Congenital insensitivity to pain with anhidrosis (CIPA)
Subcellular Location
Cell membrane
Tissue Specificity
Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.
Cell Line Specificity
Group enriched
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