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Anti-NTRK1 Monoclonal Antibody (B-4G4)
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Product Description:The Anti-NTRK1 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human NTRK1.Applications:Immunohistochemistry, Immunocytochemistry, Western Blot, ImmunoprecipitationSource:MouseTarget:NTRK1Target Species:HumanSpecificity:This antibody reacts with human Neurotrophic Receptor Tyrosine Kinase 1 (NTRK1).Immunogen:Recombinant NTRK1 proteinClonality:MonoclonalClone ID:B-4G4Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEConcentration:1 mg/mLForm:LiquidFormulation:Contact us for custom product formulation.Preservative:0.02% sodium azideShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-NTRK1 Monoclonal Antibody (B-4G4) Applications
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Recommended Dilution:Western Blot: 0.01-2 µg/mL
Immunohistochemistry: 5-20 µg/mL
Immunocytochemistry: 5-20 µg/mLNote:Optimal dilutions/concentrations should be determined by the end user.
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Protein Name
High affinity nerve growth factor receptor
Introduction
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Alternative Names
MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA
Gene ID
UniProt
Related Disease
Congenital insensitivity to pain with anhidrosis (CIPA)
Subcellular Location
Cell membrane
Tissue Specificity
Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.
Cell Line Specificity
Group enriched
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