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Anti-NTRK1 Monoclonal Antibody (MNAC13)
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Product Description:The antibody MNAC13 is a monoclonal antibody that reacts with the extracellular domain of the TrkA receptor (tropomyosin receptor kinase A). By binding to the extracellular domain of TrkA, this antibody can influence TrkA-mediated signaling pathways.Applications:Blocking, Surface Plasmon Resonance, Enzyme-Linked Immunosorbent Assay, ImmunohistochemistrySource:MouseTarget:NTRK1Target Species:HumanSpecificity:This antibody is highly specific to TrkA.Immunogen:Human NTRK1 ECD proteinClonality:MonoclonalClone ID:MNAC13Isotype:Mouse IgG1, KappaPurification:The antibody was purified by Protein A.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for customized product form or formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-NTRK1 Monoclonal Antibody (MNAC13) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
NTRK1
Protein Name
High affinity nerve growth factor receptor
Introduction
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Alternative Names
Neurotrophic Receptor Tyrosine Kinase 1; Neurotrophic Tyrosine Kinase, Receptor, Type 1; High Affinity Nerve Growth Factor Receptor; TRK1-Transforming Tyrosine Kinase Protein; Tropomyosin-Related Kinase A; Tyrosine Kinase Receptor A; EC 2.7.10.1; P140-TrkA; Gp140trk; Trk-A
Gene ID
UniProt
Related Disease
Congenital insensitivity to pain with anhidrosis (CIPA)
Subcellular Location
Vesicles,Cytosol
Tissue Specificity
Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.
Cell Type
B cells, Dendritic cells, Macrophages, Monocytes, T cells
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