Anti-NOTCH3 Monoclonal Antibody (hN3S2-160)

Subcat	Description	Isotype	Conjugate	Price
ASPR85	Anti-NOTCH3 Antibody (hN3S2-160)	Human IgG, Lambda	None	$530	Add
ASPR85-A	Anti-NOTCH3 Antibody (hN3S2-160), APC	Human IgG, Lambda	APC	$1,030	Add
ASPR85-B	Anti-NOTCH3 Antibody (hN3S2-160), Biotin	Human IgG, Lambda	Biotin	$760	Add
ASPR85-H	Anti-NOTCH3 Antibody (hN3S2-160), HRP	Human IgG, Lambda	HRP	$680	Add
ASPR85-P	Anti-NOTCH3 Antibody (hN3S2-160), PE	Human IgG, Lambda	PE	$1,280	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPR85

Anti-NOTCH3 Antibody (hN3S2-160)

Human IgG, Lambda

None

$530

Add

ASPR85-A

Anti-NOTCH3 Antibody (hN3S2-160), APC

Human IgG, Lambda

APC

$1,030

Add

ASPR85-B

Anti-NOTCH3 Antibody (hN3S2-160), Biotin

Human IgG, Lambda

Biotin

$760

Add

ASPR85-H

Anti-NOTCH3 Antibody (hN3S2-160), HRP

Human IgG, Lambda

HRP

$680

Add

ASPR85-P

Anti-NOTCH3 Antibody (hN3S2-160), PE

Human IgG, Lambda

$1,280

Add

Anti-NOTCH3 Monoclonal Antibody (hN3S2-160)
- Product Description:
  
  The anti-NOTCH3 antibody is a human monoclonal antibody recommended for Flow Cytometry, Enzyme-Linked Immunosorbent Assay. This antibody specifically targets NOTCH3 and demonstrates reactivity with human.
  
  Applications:
  
  Flow Cytometry, Enzyme-Linked Immunosorbent Assay
  
  Target:
  
  NOTCH3
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human NOTCH3.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  hN3S2-160
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Preservative:
  
  Azide free
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-NOTCH3 Monoclonal Antibody (hN3S2-160) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

NOTCH3

Protein Name

Neurogenic Locus Notch Homolog Protein 3

Introduction

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Alternative Names

NOTCH3; CASIL; Notch Homolog 3; IMF2; CADASIL; Neurogenic Locus Notch Homolog Protein 3; Notch 3

Gene ID

4854

UniProt

Q9UM47

Related Disease

Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, 1 (CADASIL1); Myofibromatosis, infantile 2 (IMF2); Lateral meningocele syndrome (LMNS)

Subcellular Location

Cell membrane
Membrane
Nucleus

Tissue Specificity

Ubiquitously expressed in fetal and adult tissues.

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