Anti-NOTCH3 Monoclonal Antibody (122M23)

Subcat	Description	Isotype	Conjugate	Price
ASPC1296	Anti-NOTCH3 Antibody (122M23)	Mouse IgG1, Kappa	None	$460	Add
ASPC1296-A	Anti-NOTCH3 Antibody (122M23), APC	Mouse IgG1, Kappa	APC	$980	Add
ASPC1296-B	Anti-NOTCH3 Antibody (122M23), Biotin	Mouse IgG1, Kappa	Biotin	$680	Add
ASPC1296-H	Anti-NOTCH3 Antibody (122M23), HRP	Mouse IgG1, Kappa	HRP	$600	Add
ASPC1296-P	Anti-NOTCH3 Antibody (122M23), PE	Mouse IgG1, Kappa	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1296

Anti-NOTCH3 Antibody (122M23)

Mouse IgG1, Kappa

None

$460

Add

ASPC1296-A

Anti-NOTCH3 Antibody (122M23), APC

Mouse IgG1, Kappa

APC

$980

Add

ASPC1296-B

Anti-NOTCH3 Antibody (122M23), Biotin

Mouse IgG1, Kappa

Biotin

$680

Add

ASPC1296-H

Anti-NOTCH3 Antibody (122M23), HRP

Mouse IgG1, Kappa

HRP

$600

Add

ASPC1296-P

Anti-NOTCH3 Antibody (122M23), PE

Mouse IgG1, Kappa

$1,180

Add

Anti-NOTCH3 Monoclonal Antibody (122M23)
- Product Description:
  
  The Anti-NOTCH3 antibody is a mouse monoclonal antibody recommended for use in immunohistochemistry, flow cytometry, western blot and other applications. This antibody specifically targets NOTCH3 and demonstrates reactivity with human.
  
  Applications:
  
  Immunohistochemistry, Flow Cytometry, Western Blot
  
  Source:
  
  Mouse
  
  Target:
  
  NOTCH3
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human NOTCH3.
  
  Immunogen:
  
  Human NOTCH3 protein.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  122M23
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-NOTCH3 Monoclonal Antibody (122M23) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

NOTCH3

Protein Name

Neurogenic locus notch homolog protein 3

Introduction

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Alternative Names

CADASIL; CADASIL1; CASIL; IMF2; LMNS

Gene ID

4854

UniProt

Q9UM47

Subcellular Location

Cell membrane

Tissue Specificity

Ubiquitously expressed in fetal and adult tissues.

Cell Line Specificity

Cancer enhanced

Function

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).

Customer Reviews

There are no reviews for Product Name.

Submit a review and receive an Amazon gift card.

Publications

There are no publications for Product Name.

If you couldn't find the specific publication, you can:
Submit a Citation Get a Publication Reward