Anti-TNFRSF10A Monoclonal Antibody (Mapatumumab)

Subcat	Description	Isotype	Conjugate	Price
ASPC1382	Anti-TNFRSF10A Antibody (Mapatumumab)	Human IgG1, Lambda	None	$460	Add
ASPC1382-A	Anti-TNFRSF10A Antibody (Mapatumumab), APC	Human IgG1, Lambda	APC	$980	Add
ASPC1382-B	Anti-TNFRSF10A Antibody (Mapatumumab), Biotin	Human IgG1, Lambda	Biotin	$680	Add
ASPC1382-H	Anti-TNFRSF10A Antibody (Mapatumumab), HRP	Human IgG1, Lambda	HRP	$600	Add
ASPC1382-P	Anti-TNFRSF10A Antibody (Mapatumumab), PE	Human IgG1, Lambda	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1382

Anti-TNFRSF10A Antibody (Mapatumumab)

Human IgG1, Lambda

None

$460

Add

ASPC1382-A

Anti-TNFRSF10A Antibody (Mapatumumab), APC

Human IgG1, Lambda

APC

$980

Add

ASPC1382-B

Anti-TNFRSF10A Antibody (Mapatumumab), Biotin

Human IgG1, Lambda

Biotin

$680

Add

ASPC1382-H

Anti-TNFRSF10A Antibody (Mapatumumab), HRP

Human IgG1, Lambda

HRP

$600

Add

ASPC1382-P

Anti-TNFRSF10A Antibody (Mapatumumab), PE

Human IgG1, Lambda

$1,180

Add

Anti-TNFRSF10A Monoclonal Antibody (Mapatumumab)
- Product Description:
  
  The Anti-TNFRSF10A antibody is a human monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, functional assay, agonist and other applications. This antibody specifically targets TNFRSF10A and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Functional Assay, Agonist
  
  Source:
  
  Human
  
  Target:
  
  TNFRSF10A
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human TNFRSF10A.
  
  Immunogen:
  
  Human TR4 protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  Mapatumumab
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-TNFRSF10A Monoclonal Antibody (Mapatumumab) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

TNFRSF10A

Protein Name

Tumor necrosis factor receptor superfamily member 10A

Introduction

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.

Alternative Names

APO2; CD261; DR4; TRAILR-1; TRAILR1

Gene ID

8797

UniProt

O00220

Subcellular Location

Cell membrane

Tissue Specificity

Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.

Cell Line Specificity

Low cancer specificity

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

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