Anti-PVR Monoclonal Antibody (2F5)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC513	Anti-PVR Antibody (2F5)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC513-P	Anti-PVR Antibody (2F5), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC513-A	Anti-PVR Antibody (2F5), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC513-H	Anti-PVR Antibody (2F5), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC513-B	Anti-PVR Antibody (2F5), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC513

Anti-PVR Antibody (2F5)

Human IgG1, Kappa

None

$460

In stock

Add

ASPC513-P

Anti-PVR Antibody (2F5), PE

Human IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC513-A

Anti-PVR Antibody (2F5), APC

Human IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC513-H

Anti-PVR Antibody (2F5), HRP

Human IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC513-B

Anti-PVR Antibody (2F5), Biotin

Human IgG1, Kappa

Biotin

$680

2-3 weeks

Add

Anti-PVR Monoclonal Antibody (2F5)
- Product Description:
  
  The Anti-PVR antibody is a human monoclonal antibody recommended for use in ELISA, western blot, flow cytometry, blocking and other applications. This antibody is specific to PVR and demonstrates reactivity with human, African green monkey.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Western Blot, Flow Cytometry, Blocking
  
  Target:
  
  PVR
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human PVR.
  
  Immunogen:
  
  Recombinant human Poliovirus Receptor protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  2F5
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-PVR Monoclonal Antibody (2F5) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

PVR

Protein Name

Poliovirus receptor

Introduction

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication.

Alternative Names

PVS; HVED; CD155; NECL5; TAGE4; Necl-5

Gene ID

5817

UniProt

P15151

Molecule Mass

Adhesion Molecules, CD Molecules, Immune Checkpoint Receptors

Cell Line Specificity

Low cancer specificity

Function

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.

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