Anti-KLRC1 Monoclonal Antibody (Z199)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC103	Anti-KLRC1 Antibody (Z199)	Human IgG4, Kappa	None	$460	In stock	Add
ASPC103-P	Anti-KLRC1 Antibody (Z199), PE	Human IgG4, Kappa	PE	$1,180	2-3 weeks	Add
ASPC103-A	Anti-KLRC1 Antibody (Z199), APC	Human IgG4, Kappa	APC	$980	2-3 weeks	Add
ASPC103-H	Anti-KLRC1 Antibody (Z199), HRP	Human IgG4, Kappa	HRP	$600	2-3 weeks	Add
ASPC103-B	Anti-KLRC1 Antibody (Z199), Biotin	Human IgG4, Kappa	Biotin	$680	2-3 weeks	Add

Anti-KLRC1 Monoclonal Antibody (Z199)
- Product Description:
  
  Z199 is an antagonist antibody that specifically recognizes human NKG2A, a receptor primarily found on natural killer (NK) cells and certain subsets of CD8+ T cells. In addition to recognizing NKG2A, Z199 also binds the CD94/NKG2A heterodimer.
  
  Applications:
  
  Blocking, Flow Cytometry
  
  Target:
  
  KLRC1
  
  Target Species:
  
  Human
  
  Specificity:
  
  Human NKG2a
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  Z199
  
  Isotype:
  
  Human IgG4, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-KLRC1 Monoclonal Antibody (Z199) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

KLRC1

Protein Name

NKG2-A/NKG2-B type II integral membrane protein

Molecular Family

Immune Checkpoint Receptors

Introduction

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternative Names

Killer Cell Lectin Like Receptor C1; Killer Cell Lectin-Like Receptor Subfamily C, Member 1; CD159 Antigen-Like Family Member A; NKG2-1/B Activating NK Receptor; NKG2-A/B-Activating NK Receptor; NK Cell Receptor A; NKG2A; NKG2-A/NKG2-B Type II Integral Membrane Protein

Gene ID

3821

UniProt

P26715

Subcellular Location

Plasma membrane

Tissue Specificity

Predominantly expressed in NK cells (at protein level). Expressed in intraepithelial CD8-positive T cell subsets with higher frequency in gamma-delta T cells than alpha-beta T cells (at protein level). Expressed in memory gamma-delta T cells (at protein level) (. Restricted to a subset of memory/effector CD8-positive alpha-beta T cells (at protein level). Expressed in intratumoral NK and CD8-positive T cells. Expressed in melanoma-specific cytotoxic T cell clones (at protein level). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed in NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level).

Cell Type

Lymphocytes, NK cells, NKT cells, T cells

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