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Anti-IL2RB Monoclonal Antibody (MiK-Beta-1)
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Product Description:The Anti-IL2RB antibody is a human monoclonal antibody recommended for use in inhibition, immunoprecipitation, blocking, ELISA, flow cytometry and other applications. This antibody specifically targets IL2RB and demonstrates reactivity with human.Applications:Inhibition, Immunoprecipitation, Blocking, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Western BlotTarget:IL2RBTarget Species:HumanSpecificity:This antibody reacts with human IL2RB.Clonality:MonoclonalClone ID:MiK-Beta-1Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-IL2RB Monoclonal Antibody (MiK-Beta-1) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
IL2RB
Protein Name
Interleukin-2 receptor subunit beta
Introduction
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system.
Alternative Names
IL2RB; interleukin 2 receptor, beta; CD122; IL15RB; P70-75; interleukin-2 receptor subunit beta; p75; IL-2RB; CD122 antigen; IL-2R subunit beta
Gene ID
UniProt
Molecule Mass
CD Molecules, Cytokine/Chemokine Receptors
Related Disease
Immunodeficiency 63 with lymphoproliferation and autoimmunity (IMD63)
Subcellular Location
Cell membrane
Cell Line Specificity
Cancer enriched
Function
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
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