COTL1

Full Name: Coactosin Like F-Actin Binding Protein 1

BACKGROUND: This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.

Synonyms: Coactosin Like F-Actin Binding Protein 1; CLP; Coactosin-Like F-Actin Binding Protein 1