Anti-COTL1 Monoclonal Antibody (H-13H12)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Size	Price	Quantity
ASZ1C446	Anti-COTL1 Antibody (H-13H12)	Mouse IgG		None		$460		Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASZ1C446

Anti-COTL1 Antibody (H-13H12)

Mouse IgG

None

$460

Add

Anti-COTL1 Monoclonal Antibody (H-13H12)
- Product Description:
  
  The Anti-COTL1 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human COTL1.
  
  Applications:
  
  Immunohistochemistry, Immunocytochemistry, Western Blot, Immunoprecipitation
  
  Source:
  
  Mouse
  
  Target:
  
  COTL1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human Coactosin Like F-Actin Binding Protein 1 (COTL1).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  H-13H12
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  0.02% sodium azide
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-COTL1 Monoclonal Antibody (H-13H12) Applications
- Recommended Dilution:
  
  Western Blot: 1:500-1:5000
  Immunohistochemistry: 1:50-1:200
  Immunocytochemistry: 1:50-1:200
  
  Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Protein Name

Coactosin-like protein

Introduction

This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.

Alternative Names

Coactosin Like F-Actin Binding Protein 1; CLP; Coactosin-Like F-Actin Binding Protein 1

Gene ID

23406

UniProt

Q14019

Subcellular Location

Cytoplasm

Tissue Specificity

Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.

Cell Line Specificity

Low cancer specificity

Function

Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.

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