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Anti-CCL17 Monoclonal Antibody (11C2)
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Product Description:The Anti-CCL17 antibody is a mouse monoclonal antibody recommended for use in ELISA and other applications. This antibody is specific to CCL17 and demonstrates reactivity with canine.Applications:Enzyme-Linked Immunosorbent AssayTarget:CCL17Target Species:CanineSpecificity:This antibody reacts with Canine CCL17.Clonality:MonoclonalClone ID:11C2Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-CCL17 Monoclonal Antibody (11C2) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
CCL17
Protein Name
C-C motif chemokine 17
Introduction
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
Alternative Names
CCL17; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 17; Small-Inducible Cytokine A17; Thymus And Activation-Regulated Chemokine; ABCD-2; T Cell-Directed CC Chemokine; TARC; A-152E5.3
Gene ID
UniProt
Subcellular Location
Secreted
Tissue Specificity
Expressed in thymus, spleen, lymph node, lung and heart.
Function
Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation (By similarity). In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation. Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (By similarity).
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