Full Name: Aminoadipate-Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase
BACKGROUND: The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia.
Synonyms: AASD-PPT; ACPS; CGI-80; LYS2; LYS5
Research Areas: Epigenetics
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