Anti-TFRC Monoclonal Antibody (OX26)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC563	Anti-TFRC Antibody (OX26)	Human IgG1, Kappa	None	$460	4-6 weeks	Add
ASPC563-1	Anti-TFRC Antibody (OX26)	Human IgG1, Kappa (S239D/A330L/I332E)	None	$460	In stock	Add
ASPC563-P	Anti-TFRC Antibody (OX26), PE	Human IgG1, Kappa	PE	$1,180	4-6 weeks	Add
ASPC563-A	Anti-TFRC Antibody (OX26), APC	Human IgG1, Kappa	APC	$980	4-6 weeks	Add
ASPC563-H	Anti-TFRC Antibody (OX26), HRP	Human IgG1, Kappa	HRP	$600	4-6 weeks	Add
ASPC563-B	Anti-TFRC Antibody (OX26), Biotin	Human IgG1, Kappa	Biotin	$680	4-6 weeks	Add

Anti-TFRC Monoclonal Antibody (OX26)
- Product Description:
  
  The Anti-TFRC antibody is a human monoclonal antibody recommended for use in ELISA and other applications. This antibody specifically targets TFRC and demonstrates reactivity with rat.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Western Blot, Flow Cytometry, Immunofluorescence, Immunohistochemistry
  
  Target:
  
  TFRC
  
  Target Species:
  
  Rat
  
  Specificity:
  
  This antibody reacts with Rat TFRC.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  OX26
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-TFRC Monoclonal Antibody (OX26) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

TFRC

Protein Name

Transferrin receptor protein 1

Introduction

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Diseases associated with TFRC include Immunodeficiency 46 and Combined T Cell And B Cell Immunodeficiency. Among its related pathways are Hematopoietic cell lineage and Insulin receptor recycling.

Alternative Names

T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46

Gene ID

64678

UniProt

Q99376

Molecule Mass

CD Molecules

Subcellular Location

Cell membrane

Tissue Specificity

In testis, expressed in Sertoli cells, peritubular myoid cells and in germinal cells. Highest levels in Sertoli cells.

Function

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity).

Customer Reviews

There are no reviews for Product Name.

Submit a review and receive an Amazon gift card.

Publications

There are no publications for Product Name.

If you couldn't find the specific publication, you can:
Submit a Citation Get a Publication Reward