Anti-SIVA1 Monoclonal Antibody (A-7B7)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Size	Price	Quantity
ASZ1C1670	Anti-SIVA1 Antibody (A-7B7)	Mouse IgG		None		$460		Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASZ1C1670

Anti-SIVA1 Antibody (A-7B7)

Mouse IgG

None

$460

Add

Anti-SIVA1 Monoclonal Antibody (A-7B7)
- Product Description:
  
  The Anti-SIVA1 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human SIVA1.
  
  Applications:
  
  Immunohistochemistry, Immunocytochemistry, Western Blot, Immunoprecipitation
  
  Source:
  
  Mouse
  
  Target:
  
  SIVA1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human SIVA1 Apoptosis Inducing Factor (SIVA1).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  A-7B7
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  0.02% sodium azide
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-SIVA1 Monoclonal Antibody (A-7B7) Applications
- Recommended Dilution:
  
  Western Blot: 1:500-1:5000
  Immunohistochemistry: 1:50-1:200
  Immunocytochemistry: 1:50-1:200
  
  Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Protein Name

Apoptosis regulatory protein Siva

Introduction

This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.

Alternative Names

CD27BP; SIVA; Siva-1; Siva-2

Gene ID

10572

UniProt

O15304

Subcellular Location

Cytoplasm

Tissue Specificity

Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.

Cell Line Specificity

Low cancer specificity

Function

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.

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