Anti-JAML Monoclonal Antibody (HL4E10)

Anti-JAML Monoclonal Antibody (HL4E10)

Cat No: ASPC1224

Summary
Host Species:
Hamster
Species Reactivity:
Mouse
Applications:
Immunofluorescence, Flow Cytometry, Surface Plasmon Resonance, Immunoprecipitation, Fluorescence-Activated Cell Sorting
Clone ID:
HL4E10
Clonality:
Monoclonal

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Product Information
Subcat Description Isotype Antibody Modification Conjugate Size Price Quantity
ASPC1224 Anti-JAML Antibody (HL4E10) Hamster IgG, Lambda None $460
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ASPC1224-A Anti-JAML Antibody (HL4E10), APC Hamster IgG, Lambda APC $980
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ASPC1224-B Anti-JAML Antibody (HL4E10), Biotin Hamster IgG, Lambda Biotin $680
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ASPC1224-H Anti-JAML Antibody (HL4E10), HRP Hamster IgG, Lambda HRP $600
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ASPC1224-P Anti-JAML Antibody (HL4E10), PE Hamster IgG, Lambda PE $1,180
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Custom Antibody We can also offer conjugation antibodies (Alexa Fluor, Cy, APC, etc.) and other format antibodies (low endotoxin, Fab, scFv, etc.)

  • Anti-JAML Monoclonal Antibody (HL4E10)
    • Product Description:
      The Anti-JAML antibody is a hamster monoclonal antibody recommended for use in immunofluorescence, flow cytometry, surface plasmon resonance, immunoprecipitation, fluorescence-activated cell sorting and other applications. This antibody specifically targets JAML and demonstrates reactivity with mouse.
      Applications:
      Immunofluorescence, Flow Cytometry, Surface Plasmon Resonance, Immunoprecipitation, Fluorescence-Activated Cell Sorting
      Target:
      JAML
      Specificity:
      This antibody reacts with JAML.
      Clonality:
      Monoclonal
      Clone ID:
      HL4E10
      Purification:
      The antibody was purified by affinity chromatography.
      Purity:
      >95% as determined by SDS-PAGE
      Aggregation:
      <5% as determined by SEC
      Concentration:
      1 mg/mL
      Form:
      Liquid
      Endotoxin:
      Please contact us for more information.
      Formulation:
      Contact us for custom product formulation.
      Preservative:
      BSA and Azide free.
      Stabilizer:
      None
      Shipping:
      Shipped at 4°C.
      Storage:
      This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
  • Anti-JAML Monoclonal Antibody (HL4E10) Applications
    • Note:
      Optimal dilutions/concentrations should be determined by the end user.
Gene Symbol
Jaml
Protein Name
Junctional adhesion molecule-like
Introduction
JAML is a transmembrane protein that belongs to the immunoglobulin superfamily and is present on various immune cells, including neutrophils and certain T cells, as well as epithelial cells. It is crucial for cell-cell adhesion and assists in the migration of leukocytes (white blood cells) across endothelial and epithelial barriers, particularly during immune responses. By interacting with the Coxsackievirus and Adenovirus Receptor (CAR) on other cells, JAML helps facilitate these processes and influences inflammatory reactions. Additionally, JAML has been linked to cancer progression and metastasis.
Alternative Names
AMICA1; adhesion molecule; interacts with CXADR antigen 1; JAML; AMICA
Gene ID
UniProt
Subcellular Location
Cell membrane
Tissue Specificity
Expressed by gamma-delta intraepithelial T cells (at protein level).
Function
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
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