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Anti-IL2RA Monoclonal Antibody (Daclizumab)
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Product Description:Daclizumab is a humanized monoclonal antibody that targets the interleukin-2 (IL-2) receptor alpha chain (also known as CD25). The epitope for daclizumab is located on the CD25 molecule. CD25 is expressed on the surface of activated T cells and regulatory T cells, and it plays a crucial role in the IL-2 signaling pathway, which is important for T cell proliferation and function. By binding specifically to CD25, daclizumab blocks IL-2 from binding to its receptor, thereby inhibiting the IL-2 mediated activation and proliferation of T cells.Applications:Enzyme-Linked Immunosorbent Assay, Blocking, Flow Cytometry, Functional AssayTarget:IL2RATarget Species:HumanSpecificity:Humna interleukin-2 receptor alpha chainClonality:MonoclonalClone ID:DaclizumabIsotype:Human IgG1, KappaPurification:The antibody was purified by Protein A.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for customized product form or formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-IL2RA Monoclonal Antibody (Daclizumab) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
IL2RA
Protein Name
Interleukin-2 receptor subunit alpha
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Introduction
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Alternative Names
Interleukin 2 Receptor Subunit Alpha; IL2RA
Gene ID
UniProt
Related Disease
Type 1 diabetes mellitus 10 (T1D10)
Cell Type
B cells, Lymphocytes
Function
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
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