Anti-HLA-DR Monoclonal Antibody (L243)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC135	Anti-HLA-DR Antibody (L243)	Mouse IgG2a, Kappa	None	$460	In stock	Add
ASPC135-P	Anti-HLA-DR Antibody (L243), PE	Mouse IgG2a, Kappa	PE	$1,180	2-3 weeks	Add
ASPC135-A	Anti-HLA-DR Antibody (L243), APC	Mouse IgG2a, Kappa	APC	$980	2-3 weeks	Add
ASPC135-H	Anti-HLA-DR Antibody (L243), HRP	Mouse IgG2a, Kappa	HRP	$600	2-3 weeks	Add
ASPC135-B	Anti-HLA-DR Antibody (L243), Biotin	Mouse IgG2a, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC135

Anti-HLA-DR Antibody (L243)

Mouse IgG2a, Kappa

None

$460

In stock

Add

ASPC135-P

Anti-HLA-DR Antibody (L243), PE

Mouse IgG2a, Kappa

$1,180

2-3 weeks

Add

ASPC135-A

Anti-HLA-DR Antibody (L243), APC

Mouse IgG2a, Kappa

APC

$980

2-3 weeks

Add

ASPC135-H

Anti-HLA-DR Antibody (L243), HRP

Mouse IgG2a, Kappa

HRP

$600

2-3 weeks

Add

ASPC135-B

Anti-HLA-DR Antibody (L243), Biotin

Mouse IgG2a, Kappa

Biotin

$680

2-3 weeks

Add

Anti-HLA-DR Monoclonal Antibody (L243)
- Product Description:
  
  L243 is a monoclonal antibody that specifically binds to the HLA-DR antigen, a major histocompatibility complex (MHC) class II cell surface receptor. The epitope recognized by L243 is conformational and relies on the proper folding of the HLA-DRα/β heterodimer.
  
  Applications:
  
  Immunoprecipitation, Western Blot, Blocking, Flow Cytometry, Immunofluorescence, Immunohistochemistry
  
  Source:
  
  Mouse
  
  Target:
  
  HLA-DR
  
  Target Species:
  
  Human
  
  Specificity:
  
  HLA-DR antigen
  
  Immunogen:
  
  Human B cell line RPMI 8866
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  L243
  
  Isotype:
  
  Mouse IgG2a, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-HLA-DR Monoclonal Antibody (L243) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

HLA-DRA

Protein Name

HLA class II histocompatibility antigen, DR alpha

Introduction

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.

Alternative Names

HLA-DRA1; HLA class II; HLA class II histocompatibility antigen; Histocompatibility antigen HLA-DR alpha

Gene ID

3122

UniProt

P01903

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