Anti-B. anthracis Lethal factor Monoclonal Antibody (F5-1)

Subcat	Description	Isotype	Conjugate	Price
ASPC909	Anti-B. anthracis Lethal factor Antibody (F5-1)	Human IgG1, Kappa	None	$460	Add
ASPC909-A	Anti-B. anthracis Lethal factor Antibody (F5-1), APC	Human IgG1, Kappa	APC	$980	Add
ASPC909-B	Anti-B. anthracis Lethal factor Antibody (F5-1), Biotin	Human IgG1, Kappa	Biotin	$680	Add
ASPC909-H	Anti-B. anthracis Lethal factor Antibody (F5-1), HRP	Human IgG1, Kappa	HRP	$600	Add
ASPC909-P	Anti-B. anthracis Lethal factor Antibody (F5-1), PE	Human IgG1, Kappa	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC909

Anti-B. anthracis Lethal factor Antibody (F5-1)

Human IgG1, Kappa

None

$460

Add

ASPC909-A

Anti-B. anthracis Lethal factor Antibody (F5-1), APC

Human IgG1, Kappa

APC

$980

Add

ASPC909-B

Anti-B. anthracis Lethal factor Antibody (F5-1), Biotin

Human IgG1, Kappa

Biotin

$680

Add

ASPC909-H

Anti-B. anthracis Lethal factor Antibody (F5-1), HRP

Human IgG1, Kappa

HRP

$600

Add

ASPC909-P

Anti-B. anthracis Lethal factor Antibody (F5-1), PE

Human IgG1, Kappa

$1,180

Add

Anti-B. anthracis Lethal factor Monoclonal Antibody (F5-1)
- Product Description:
  
  The Anti-B. anthracis Lethal factor antibody is a human monoclonal antibody recommended for use in enzyme-linked immunosorbent assay and other applications. This antibody specifically targets B. anthracis Lethal factor.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay
  
  Source:
  
  Chimpanzee
  
  Target:
  
  B. anthracis Lethal factor
  
  Target Species:
  
  Bacillus anthracis
  
  Specificity:
  
  This antibody reacts with B. anthracis Lethal factor.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  F5-1
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-B. anthracis Lethal factor Monoclonal Antibody (F5-1) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

lef

Protein Name

Lethal factor

Introduction

Bacillus anthracis, the bacterium responsible for anthrax, secretes two primary toxins, one of which is the lethal factor. This toxin is a zinc-dependent metalloprotease that collaborates with the protective antigen (PA) to infiltrate host cells. Once inside, it cleaves mitogen-activated protein kinase kinases (MAPKKs), disrupting crucial cell signaling pathways. This disruption can result in cell death, tissue damage, and may lead to severe circulatory shock, posing a fatal risk to the infected host.

Alternative Names

lef; LF; Lethal factor; Anthrax lethal toxin endopeptidase component; Bacillus anthracis Lethal factor

Gene ID

45025515

UniProt

P15917

Subcellular Location

Secreted

Function

Lethal factor (LF), which constitutes one of the three proteins composing the anthrax toxin, is able to trigger rapid cell death in macrophages. Acts as a protease that cleaves the N-terminal of most dual specificity mitogen-activated protein kinase kinases (MAPKKs or MAP2Ks) (except for MAP2K5): cleavage invariably occurs within the N-terminal proline-rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein-protein interactions necessary for the assembly of signaling complexes.

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