Full Name: U1 small nuclear ribonucleoprotein A
BACKGROUND: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5 splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5-UGCAC-3 motif on RNAs.
Synonyms: SNRPA; U1 SnRNP-Specific Protein A; Mud1; U1 Small Nuclear Ribonucleoprotein A; U1-A; U1 SnRNP A; Small Nuclear Ribonucleoprotein Polypeptide A; U1 Small Nuclear RNP-Specific A
Research Areas: Metabolism
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